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Objective and design It is believed that correction of membrane fatty acid deficiency in cystic fibrosis (CF) downregulates the synthesis of proinflammatory mediators. We tested the hypothesis that an increase of the proportion of docosahexaenoic acid (DHA) in the membrane in vitro changes the neutrophil response to Pseudomonas aeruginosa lipopolysaccharide (LPS). Results Treatment with DHA increased...
Macrophages play a pivotal role in a host's defence against pulmonary infections. Macrophage functions are impaired in immunosuppressed (IS) patients, regardless of whether they are HIV-positive (HIV+) or –negative (HIV−). Several studies have indicated that urokinase plasminogen activator (uPA) and transforming growth factor β (TGF-β) are important factors in a host's defence against pulmonary pathogens...
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