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In den Begriff Ischmie-Reperfusionsschaden werden alle toxischen Ereignisse fr eine Zelle whrend einer Ischmie und einer anschlieenden Reoxygenierung einbezogen. Diese Reaktionen haben beispielsweise einen bedeutenden Einfluss auf die Organberlebensraten bei Nierentransplantation. Entscheidenden Anteil am postischmischen Reperfusionsgeschehen haben reaktive Sauerstoffintermediate (ROI). Die grundstzlichen...
Abstract Ischemia-reperfusion injury is known to induce the inducible form of the 70 kDa heat shock protein HSP70 i (or HSP72) mainly via rapid activation of heat shock transcription factor 1 (HSF1). However, little is known about the regulation of the HSF1 gene. We therefore studied the time course of HSF1 mRNA transcription and its relation to the expression pattern of the HSP70 i mRNA in the renal...
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