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Whole exome sequencing (WES) is a widely used technique in both medical studies and clinical practice. However, a number of studies show that the results produced by different WES analysis pipelines are not always homogeneous. To this end, we propose a method (called Genomedics) using a consensus approach to expand the list of variants by combining results called from six separate pipelines with sensitive...
The discovery of RNA interference (RNAi) leads to design novel drugs for different diseases. Selecting short interfering RNAs (siRNAs) that can knockdown target genes efficiently is one of the key tasks in studying RNAi. A number of predictive models have been proposed to predict knockdown efficacy of siRNAs, however, their performance is still far from the expectation. This work aims to develop a...
Background Short interfering RNAs (siRNAs) can knockdown target genes and thus have an immense impact on biology and pharmacy research. The key question of which siRNAs have high knockdown ability in siRNA research remains challenging as current known results are still far from expectation. Results This work aims to develop a generic framework to enhance siRNA knockdown efficacy prediction. The...
This paper is concerned on FPGA design for control implementations of four switch three phase inverters (B4, FSTPI). This paper is to present a space vector PWM algorithm for four switch three phase inverters (B4, FSTPI) based on the one for six switch three phase inverters (B6, SSTPI) (principle of similarity) where the ???? plan is divided into 6 sectors and the formation of the required reference...
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