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In vivo longitudinal and repetitive cellular-level visualization of microvasculature and fluorescent cells in deep tissue such as skin dermis, solid tumor and brain of single mouse in minimally invasive manner was demonstrated by using a needle-type side-view confocal endomicroscopy.
In this study, a novel oral insulin delivery system was prepared by combining two different artificial polypeptides with insulin. Negatively charged poly(l-glutamate-co-N-3-l-glutamylsulfanilic acid) (PLGS), cationic alpha helical peptide poly-l-lysine (PLL), and insulin formed polyelectrolyte complexes (PCs) were characterized. The property of the PCs was examined by an in vitro study. A significantly...
By utilizing custom-design high-speed video-rate laser-scanning confocal microscope system for visualizing fast-flowing cells at the great saphenous vein of mouse, we quantitated circulating tumor cells of whole body blood, in vivo, by hemocytometric imaging analysis.
By utilizing custom-design video-rate near-infrared laser-scanning confocal microscope, we imaged the pharmacokinetic dynamics of intravenously injected ICG at the skin and liver of mouse in sub-cellular scale in vivo.
In vivo Longitudinal repetitive observation of microvasculature and fluorescent cells in a small intestinal tract of single mouse in minimally invasive manner was demonstrated by using GRIN lens based side-view confocal endomicroscopy.
We present an in vivo lung imaging of murine model for pulmonary disease by using custom-design video-rate laser-scanning confocal microscopy integrated with suction chamber for motion stabilization.
We established an intravital high-speed laser-scanning confocal microscopy capable of visualizing fast-flowing individual cells at great saphenous vein of mouse model and quantified circulating tumor cells of whole body blood, in vivo, by image-based analysis.
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