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We present angle-resolved terahertz time-domain spectroscopy (THz TDS) measurements of poly(butylene) terephthalate (PBT) and compare the results to x-ray scattering measurements. This comparison confirms that the THz TDS measurements can be correlated to the crystal structure. Further, the THz TDS measurements give insights into the binding energies of the crystal bounds.
Pathogens commonly utilize endocytic pathways to gain cellular access. The endosomal pattern recognition receptors TLR7 and TLR9 detect pathogen-encoded nucleic acids to initiate MyD88-dependent proinflammatory responses to microbial infection. Using genome-wide RNAi screening and integrative systems-based analysis, we identify 190 cofactors required for TLR7- and TLR9-directed signaling responses...
Homing endonucleases are highly specific DNA endonucleases, encoded within mobile introns or inteins, that induce targeted recombination, double-strand repair and gene conversion of their cognate target sites. Due to their biological function and high level of target specificity, these enzymes are under intense investigation as tools for gene targeting. These studies require that naturally occurring...
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