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Background NSC260594, a quinolinium derivative from the NCI diversity set II compound library, was previously identified in a target-based assay as an inhibitor of the interaction between the HIV-1 (ψ) stem-loop 3 (SL3) RNA and Gag. This compound was shown to exhibit potent antiviral activity. Here, the effects of this compound on individual stages of the viral lifecycle were examined by qRT-PCR,...
Based on the Large Eddy Simulation (LES) turbulent model, the three-dimensional internal viscous flow field of the mine fan diffuser was solved with Reynolds-averaged Navier-Stokes (RANS) equations. The numerical simulation results show good agreements with experimental ones. The relative error was less than 5%, and the validation of the numerical simulation method was verified. Using the solution...
Mitofusin 2 (Mfn2) is an important suppressor of vascular smooth muscle cell (VSMC) proliferation. It contains a protein kinase A (PKA) phosphorylation site at serine 442 (S442) and can be phosphorylated by PKA. This study examined the role of phosphorylating specific sites on the regulation of Mfn2 protein activity in vitro and in vivo.We introduced two mutations at S442 in rat Mfn2, and investigated...
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