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There have been a lot of researches about aging. Our study suggests a new research method using RTEL (Regulator of Telomere Elongation Helicase). Telomere is the region of repetitive DNA sequence at the end of chromosomes used as a buffer during the DNA replication. We made four sets (each set includes 3 mammals whose lifespan is almost similar) which have different lifespan range, and compared the...
As a critical role in overall human body reactions to foreign organisms, innate immune system, especially Mannose-binding lectin (MBL), has worked for the preservation of life. Since targeted therapy on bacterial infection using innate immune system has been researched for destroying pathogens without harming ourselves, MBL could be used for the targeted therapy. Based on three algorithms; Decision...
Nowadays, zika virus infection-occurred in Brazil-is becoming serious global problem. Temporary treatments-using drug-can alleviate symptoms for a while but cannot be a basic solution for infections. We researched amino acids of Zika virus and other four kinds of flaviviruses-Dengue fever, Yellow fever, Saint Louis, Japanese Encephalitis-with bioinformatic experiment; Apriori, K-means and Decision...
Middle East Respiratory Syndrome is a respiratory disease spread by MERS Coronavirus, which had its first occurrence in Kingdom of Saudi Arabia. In this paper, we analyzed the transmission route of MERS-CoV with a novel molecular approach. We collected the amino acid sequence of MERS-CoV from 15 different regions, which were then analyzed with Neural Network and Support Vector Machine. With the usage...
This research aims to discover validate the endosymbiotic theory of chloroplast by comparing chloroplast DNA and cyanobacterial DNA using computational methods such as apriori and decision tree. We compared the nucleotide sequences of four plants that each represent four evolutionary classes, bryophytes, pterophyts, gymnosperms, and angiosperms, and Synechococcus DNA. The rules extracted from five...
Dementia with Lewy bodies and Parkinson's Disease has the common cause: mutation of gene CYP2D6. Thus, it is hard to distinguish those two diseases. In order to classify them clearly, construction of sorting machine is required. Various algorithms including Apriori, Decision tree, Support Vector Machine, K-means and Neural Network was used in the construction of sorting machine. Two kinds of sorting...
The Herpes Simplex is a common fluid-intermitted disease that is common among not only adults but also children. Several symptoms include blisters and sores forming on infection sites that are mainly located in oral and genital body parts. The two main types of viral infection, commonly referred to as HSV-1 and HSV-2, are both part of the same Herpes Simplex Virus group (HSV), but they exhibit different...
The paper introduces a prototype of an algorithm that creates personalized news articles about IT and technology based on each personal preference for a specific theme, criteria, or element. When provided a specific personal preference, the algorithm Custombot analyses the data, derives the most appropriate topic that contains the most elements preferred by a person, and eventually produces a one...
Flavivirus is spreaded with the help of intermediary, especially mosquitoes. In preceding research, we found out that Leucine has high frequency. Wanting to know specific relationship between 5 flaviviruses; Yellow fever, West Nile virus, Dengue virus, Tick borne encephalitis, decision tree and support vector machine algorithm were used. Analyzing results of the algorithms, difference or similarity...
Bioinformatics is an interdisciplinary academic field that analyzes biological data using modern techniques. However, there are several drawbacks that can threaten the credibility of analyses using bioinformatics because of the massive quantity of data. So, in this paper, we suggested a new DNA sequence data-compressing method called “Binaling”. We effectively compressed DNA sequence data using the...
Middle East Respiratory Syndrome, which is a respiratory disease caused by MERS coronavirus, is known to be an endemic disease spread in Kingdom of Saudi Arabia, or KSA. On May 20, 2015, it has massively occurred in Republic of Korea, with 186 confirmed cases, 36 deaths. In this paper, we analyzed some features of MERS-CoV's transmission route by a new molecular approach. We have collected DNA sequences...
This study focuses on the mosquito borne diseases including dengue-1, dengue-4, yellow fever, west nile virus infection, and filariasis. These are the diseases that are typically shown in the African continent and Eastern Asia, which are the places that suffer from poverty the most. Vaccines for some of the diseases have already been made but the ones who inhabit in those areas do not have the ability...
This study focuses on the mosquito borne diseases including dengue-1, dengue-4, yellow fever, west nile virus infection, and filariasis. These are the diseases that are typically shown in the African continent and Eastern Asia, which are the places that suffer from poverty the most. Vaccines for some of the diseases have already been made but the ones who inhabit in those areas do not have the ability...
Middle East Respiratory Syndrome, which is a respiratory disease caused by MERS coronavirus, is known to be a endemic disease spread in Kingdom of Saudi Arabia, or KSA. On May 20, 2015, it has massively occurred in Republic of Korea, with 186 confirmed cases, 36 deaths. In this paper, we analyzed some features of MERS-CoV's transmission route by a new molecular approach. We have collected DNA sequences...
Although there are a lot of advances in treating cancer, lung cancer is still the top ranked killer cancer taking millions of people's lives. For heavy patients, targeted therapy is commonly used to delay the progress of cancer. However, different mutations that cause lung cancer need different drugs for the treatment. In order to find similarities between mutations, we conducted an experiment using...
Cancer is currently a major cause of death, which resulted in great interest in the mechanisms of this disease, and how to prevent or cure it. Certain cytokines are spotlighted to be a key to solving this problem, since they play a role in the immune system against cancer. Thus, our goal is to analyze various cytokines and to mine their rules. In this study, we aimed to mine a common rule between...
DFNA5's mutations are known as the reason of autosomal dominant non-syndromic hearing loss (ADNSHL). To date, DFNA5 has been mostly experimented by particular families' DNA samples. By using three homo sapiens deafness sequences provided by ncbi, we investigated amino acid sequences in order to analyze relationships among mutants. We used apriori algorithm to find common amino acid which indicates...
Both M81 and B95-8 are distinct strains belonged to Epstein-Barr Virus (EBV). However, as M81's target cell is epithelial cell and that of B95-8 is B cell, and common EBV vaccine only causes an effect only on B95-8, we can recognize that these two EBVs have different characteristics. In this paper, we analyzed DNA sequence using three algorithms: Apriori, Decision Tree, and support vector machine...
Even as the modern protein sequencing technology is uncovering great amount of new protein, such data are futile without knowledge of the functions the protein sequences encode. To overcome the limitation of experimental analysis, utilizing Support Vector Machine and kernel methods for functional prediction of unannotated protein has become a promising topic of research in the field of computational...
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