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Fenofibrate, an oral fibrate lipid lowering agent, and simvastatin, which reduces plasma levels of low-density lipoprotein cholesterol, are active pharmaceutical ingredients (APIs), currently in the market. We characterized these APIs by thermal analysis and conducted X-ray powder diffraction techniques. Studies should be carried out in the formulation stage before the final composition of a polypill...
In this paper the design of state observers or software sensors for a biological process of ethanol production by S. cerevisiae is presented. Two observers (non-linear and sliding) were used for monitoring continuous fermentations. Their performances were evaluated using mathematical model for bioreactor (perfect knowledge of both model structure and parameters. The performance of the observers proposed...
This paper presents a comparative analysis of two nonlinear state estimators applied to the production process of tequila. The estimates consist of an extended Kalman filter (EKF) and a sliding mode observer (SMO), which are assessed to changes in process inputs and model parametric changes. The estimates are used to estimate the microbial growth and production of alcohol from the measurement of glucose...
A local analysis of stability and observability of the ethanol process are determined for continuous operation. It is found that the process is stable and noncompletely observable in the selected steady states. The analysis of observability was studied in terms of the observability matrix rank conditions. Furthermore, we design a nonlinear observer in order to estimate the observable state variables...
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