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Lipids and lipoproteins concentration in human plasma are directly correlated to the risk of C cardiovascular diseases. Enumeration of certain classes of lipoproteins by their size, e.g. mean and modal diameter, wants to be developed in alternative of the traditionally used method based of their density. Traceable size measurement of certified nanospheres were performed by AFM, obtaining resolution...
Recent studies recognized the cell stiffness changes as a marker for cancer detection. Reliable and reproducible measurements of elastic modulus, mapping different cell regions are the basis for developing a new methodology for cancer detection. To this aim, a metrological characterized AFM microscope has been developed, micro- and nano-indentation of soft materials, used as elastic modulus reference,...
The validation of the AFM method for elastic modulus E measurement in soft materials (E <5MPa) is still missing. The interest of measurements in materials with E <5MPa is mainly biological, including soft tissues and single cells. For the diagnosis of malignant human tumors, a change in cell elasticity, within tissues, has recently been recognized as a marker of metastatic potential. To measure...
Cytomorphological- and immunofluorescence-based methods are currently use for the diagnosis of malignant human tumors. However, morphological overlaps between tumor and normal cell types frequently occur. Recently, a change in cell elasticity of tissues has been recognized as a marker of tissues metastatic potential. Atomic force Microscope (AFM) can quantitatively distinguish cancer and normal cells...
Coherent anti‐Stokes Raman scattering (CARS) microscopy is used in conjunction with second harmonic generation (SHG) to follow the early stage of stem cell differentiation within a three‐dimensional (3D) scaffold. Formation of an extracellular matrix mainly composed of collagen is one of the first signs of human mesenchymal stem cell (hMSC) differentiation. This work shows that the multimodal CARS...
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