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Nowadays, cells are commonly used for predicting whether the drug compounds will be effective and safe in human. The response of cell groups was usually analyzed, instead of single cell. However, individual cells within the same population even shows various characteristics. Understanding this heterogeneity is critical to studying how effective therapies will be in the clinic. Therefore, highly efficient...
In article number 1602769, H. Yu, L. Liu, and co‐workers demonstrate a Tetris‐inspired approach to fabricate 3D heterogeneous microscale tissue from hydrogel building blocks. The investigated system combines optofluidic maskless lithography and optically induced dielectrophoresis (ODEP). The customized bio‐microstructures in Tetris shapes are dynamically synthesized using an optofluidic maskless lithography...
3D hydrogel microstructures that encapsulate cells have been used in broad applications in microscale tissue engineering, personalized drug screening, and regenerative medicine. Recent technological advances in microstructure assembly, such as bioprinting, magnetic assembly, microfluidics, and acoustics, have enabled the construction of designed 3D tissue structures with spatially organized cells...
Fabrication of cell growth environment in vitro to control the cell spatial arrangement and proliferation is an indispensable technique for cell-based technologies. Previously several developed micropatterning methods such as soft lithography required relatively complicated operations, which leads to difficulties in the following research to investigate the effects of different cell growth patterns...
Patterned microstructures of hydrogels have attracted significant attention due to an increasing need for developing scaffolds for tissue engineering, as carriers for drug delivery, and as extracellular matrices for biological studies. However, current tissue engineering approaches lack the flexibility required for developing complex two or three-dimensional (2D/3D) microstructures, which are used...
Fabrication of extracellular microenvironment for cancer cell growth in vitro is an indispensable technique to precisely control the cell spatial arrangement and proliferation for cell-behavior research. Current micropatterning methods usually require relatively complicated operations, which makes it difficult to investigate the effects of different cell growth patterns. This manuscript proposes a...
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