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Purpose
To investigate the effect of the analysis technique on estimating hepatic iron content using MRI.
Materials and Methods
We evaluated the influences of single‐exponential (EXP), bi‐exponential (BEXP), and exponential‐plus‐constant (CEXP) models; and pixel‐wise (MAP), average (AVG), and median (MED) signal calculation methods on T2* measurement using numerical simulations, calibrated phantoms,...
Iron toxicity is the major cause of tissue damage in patients with iron overload. Iron deposits mainly in the liver, where its concentration closely correlates with whole body iron overload. Different techniques have been proposed for estimating iron content, with liver biopsy being the gold standard despite its invasiveness and influence by sampling error. Recently, magnetic resonance imaging (MRI)...
Iron toxicity is the major factor for tissue damage and organ failure in patients with iron overload. T2∗ measurement with magnetic resonance imaging (MRI) has been established as an effective and non-invasive technique for evaluating iron content in the liver. However, different factors related to the adopted image processing criterion affect the resulting measurements. These factors include the...
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