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The design process of mechatronic devices, which involves experts from different disciplines working together, has limited time and resource constraints. These experts normally have their own domain-specific designing methods and tools, which can lead to incompatibilities when one needs to work together using these those methods and tools. Having a proper framework which integrates different design...
In this paper we use eQTL mapping to identify associations between gene dysregulation and single nucleotide polymorphism (SNP) genotypes in glioblastoma multiforme (GBM). A set of 532,954 SNPs was evaluated as predictors of the expression levels of 22,279 expression probes. We identified SNPs associated with fold change in expression level rather than raw expression levels in the tumor. Following...
The work presented here is on a methodology for design of hard real-time embedded control software for robots, i.e. mechatronic products. The behavior of the total robot system (machine, control, software and I/O) is relevant, because the dynamics of the machine influences the robot software. Therefore, we use two appropriate Models of Computation, which represent continuous-time equations for the...
This paper describes a collaborative modelling exercise using the DESTECS framework. The DESTECS approach allows engineers and software designers to collaborate to produce system models that contain a discrete-event (DE) model of a controller and continuous-time (CT) model of a plant. We call these models co-models and call their execution co-simulation. The DESTECS tool couples existing DE and CT...
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