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We demonstrate a diagnostics platform which integrates an ISFET array and a temperature control loop for isothermal DNA detection. The controller maintains a temperature of 63°C to perform nucleic acid amplification which is detected by the on-chip sensors. The 32×32 ISFET array is first calibrated to cancel trapped charge and then measures the change in the pH of the reaction. The sensor data is...
This paper introduces a CMOS based system that has been designed to allow parallel comparison of fragmented DNA sequences for on-chip assembly. The compatibility of different existing PC-based algorithms for implementation in CMOS is compared and the overlap-layout-consensus approach is found to be the most suitable one. The designed system comprises a scalable processing array capable of parallel...
We demonstrate a CMOS-based lab-on-chip platform for combined magnetic manipulation and opto-chemical sensing. Each pixel of the 8×8 array integrates a Programmable Gate (PG) ISFET chemical sensor and an active pixel sensor, encompassed within an inductive coil. The system can be used for simultaneous optical imaging and pH sensing, and includes an auto-calibration mechanism for eliminating sensor...
This paper describes an integrated ISFETs instrumentation system in a 0.18 μm 1-poly-6-metal CMOS process. The chip is able to compute the average of CMOS ISFETs' threshold voltages by using an averaging array employing global negative current feedback. In addition, neither reference voltage nor current is required to set up the sigma-delta modulator because the internal signal is converted and processed...
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