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Adult Schwann cells cultured within three-dimensional (3D) collagen-based nervous tissue constructs demonstrated downstream migration and potential use in the contact-guidance of regenerating adult dorsal root ganglia (DRG) axons. Type I collagen extracted from rat tail tendons was used to prepare collagen dispersions for wet spinning micron-size collagen fibers. Biodegradable poly-L-lactic acid (PLLA)...
The purpose of this work is to design novel, modular devices in order to reproduce traumatic brain injury in the rat and mouse models: fluid percussion injury (FPI), controlled cortical impact (CCI) and the Shock tube. Commercially available TBI devices are often unimethodical, expensive and sensitive to experimental variability. To achieve maximum control and sensitivity, in our first device, we...
Type I collagen was extruded into well-defined fibers using a novel controlled wet spinning device. The device significantly improved the yield of collagen fibers on the micron scale. Collagen scaffold materials fabricated from the device will provide contact-guided growth of neuronal cultures. Fibers composed of different weight percentages, 75, 2, and 3.4 wt% collagen dispersions, were used to validate...
Three-dimensional (3D) nervous tissue constructs were developed using a compliant gel matrix and a fiber component for promoting contact-guided axon outgrowth. Rat embryonic (E15) dorsal root ganglion expiants (DRGs) were cultured on biodegradable poly-L-lactic acid (PLLA) and wet-spun type I collagen fibers embedded in soft collagen gels. Gel constructs containing fibers induced greater axon outgrowth...
A novel, modular device was designed to reproduce two traumatic brain injury models used in the rat and mouse: fluid percussion injury (FPI) and controlled cortical impact (CCI). Commercially available TBI devices are often unimethodical, expensive and sensitive to experimental variability. To achieve maximum control and sensitivity, we utilized a closed loop voice coil control device to more accurately...
The transition from embryo to adulthood involves a massive growth in the nervous system where axons in nerves extend and expand to accommodate to this growth. Applying mechanical forces to dorsal root ganglia neuronal cultures has previously shown that there is stimulation in axonal growth, gradually elongating the axon over a set period of time. In this research, the main focus is to study with live...
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