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Although mitochondrial dysfunction is a consistent feature of Alzheimer's disease in the brain and blood, the molecular mechanisms behind these phenomena are unknown. Here we have replicated our previous findings demonstrating reduced expression of nuclear-encoded oxidative phosphorylation (OXPHOS) subunits and subunits required for the translation of mitochondrial-encoded OXPHOS genes in blood from...
Diabetes mellitus is a serious and widespread disease currently affecting 25.8 million people in the United States. Its treatments including exercise, diet, hypoglycemic pills, and insulin often are not sufficient to mitigate the symptoms of the disease or prevent its progression over time. An artificial pancreas capable of continuously monitoring and adjusting blood glucose levels through closed-loop...
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