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We have imaged several breast cancer patients at multiple intervals during her neoadjuvant chemotherapy to assess the capability of microwave tomography as a therapy monitoring device. For the patient discussed here, we illustrate the spectral behavior of our tomographic approach in the context of a complex imaging situation with a large scattering tumor along with less frequently encountered structures...
Osteoporosis is a major health problem affecting roughly 55% of the U.S. population 50 years of age or older. Current methods to detect osteoporosis or assess bone fracture risk involve a bone mineral density (BMD) exam generally using x-ray techniques - primarily dual x-ray absorptiometry (DXA). While this technique provides a measure of the bone mass, it does not offer any insight into bone quality,...
Microwave imaging is based on recovering the electrical properties, namely permittivity and conductivity, of materials. Microwave imaging for biomedical applications is particularly interesting, because the available range of dielectric properties of different tissues can provide substantial functional information about their health. Breast cancer detection and treatment response monitoring are areas...
We are developing a microwave tomographic system for assessment of overall bone health. We hypothesize that as the mineralization of bone decreases due to the normal aging process and for more extreme situations such as osteoporosis, the dielectric property signature will also vary accordingly. To determine the merits of this approach, we have begun by performing initial exams of the heel to assess...
In Arabidopsis thaliana, the Toc34 receptor component of the chloroplast import machinery is encoded by two independent but highly homologous genes, atToc33 and atToc34. We have isolated a T-DNA insertion mutant of atToc33 which is characterized by a pale phenotype, due to reductions in the levels of photosynthetic pigments, and alterations in protein composition. The latter involve not only chloroplast...
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