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Background
Clinical studies demonstrated peripheral nociceptor deficit in stress‐related chronic pain states, such as fibromyalgia. The interactions of stress and nociceptive systems have special relevance in chronic pain, but the underlying mechanisms including the role of specific nociceptor populations remain unknown. We investigated the role of capsaicin‐sensitive neurones in chronic stress‐related...
Protease-activated receptor-2 (PAR-2) is a G-protein-coupled receptor activated through proteolytic cleavage. It is localized on epithelial, endothelial and inflammatory cells, as well as on transient receptor potential vanilloid 1 (TRPV1) receptor-expressing neurones. It plays an important role in inflammatory/nociceptive processes. Since there are few reports concerning PAR-2 function in joints,...
The case study presents modern robust control methods of the Bergman minimal model of Type I diabetic patients under intensive care using computer algebra: the disturbance rejection LQ control or minimax control (as extension of the classical LQ control) and the robust H?? control. It is shown the minimax control has limitations in practice, but employing reduced Gro??bner basis on rational field,...
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