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Tonotopy is a hallmark of auditory pathways and provides the basis for sound discrimination. Little is known about the involvement of transcription factors in brainstem cochlear neurons orchestrating the tonotopic precision of pre-synaptic input. We found that in the absence of Hoxa2 and Hoxb2 function in Atoh1-derived glutamatergic bushy cells of the anterior ventral cochlear nucleus, broad input...
Polycomb repressive complexes PRC1 and PRC2 regulate expression of genes involved in proliferation and development. In mouse early embryos, however, canonical PRC1 localizes to paternal pericentric heterochromatin (pat-PCH), where it represses transcription of major satellite repeats. In contrast, maternal PCH (mat-PCH) is enriched for H3 lysine 9 tri-methylation (H3K9me3) and Hp1β. How PRC1 is targeted...
In the last decade “Demon”-based matching algorithms have largely demonstrated their efficiency in non-rigid registration of clinical and biomedical images. This paper present an experimental study of a symmetrized variant of Thirion's demons algorithm applied to the realignment of 3D images obtained by serial block face scanning electron microscopy (SBFSEM). Because demons are sensible to local intensity...
Cone-beam computed tomography (CT) using X-ray tubes of high energy (450 keV) faces the problem of strong artifacts and a significant contrast degradation in reconstructed images. System components of cone-beam CT scanners operating at high X-ray energies have to be optimized to reduce the amount of scattered photons hitting the detector. In addition it is mandatory to apply scatter correction algorithms...
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