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The feasibility of inducing and imaging thermal strain to identify vulnerable plaques in peripheral arteries based on conventional ultrasound scanners is demonstrated. Vulnerable plaque usually consists of a large lipid-rich core. Because lipid-bearing tissue has a negative temperature dependence of sound speed, whereas water-based tissue has a positive one, thermal strain imaging can differentiate...
Thermal strain imaging (TSI) using intravascular ultrasound (IVUS) has the potential to identify lipid pools within rupture-prone arterial plaques and serve as a valuable supplement to current IVUS systems in diagnosing acute coronary syndromes. The major challenge for in vivo application of TSI will be cardiac motion, including bulk motion and tissue deformation. Simulations based on an artery model,...
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