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In our study, a recombinant adenovirus based on the avian adenovirus CELO genome, has been constructed that contains the human interleukin-2 gene. We have shown the production of biologically active recombinant interleukin-2 in vitro (LMH and 293 cells) and in ovo (chicken embryos) infected with recombinant virus CELO-IL2. An increase in the median survival time of C57BL/6 mice carrying B16 melanoma...
Introduction: While studying functional activity of cortisone-resistant (CR) thymocytes we have found, that these cells spontaneously produce mediators. These factors show immunomodulating activity. The gained data allow us to assume that these thymocytes produce new, unknown cytokines, first of all, a chemotactic factor, inducing migration of stem elements from marrow to different lymphoid organs...
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