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Silicon smart microchips with CMOS/MEMS technology are realized for Intelligent sensing. In our developed chips, new type sensor chips for bio-medical applications are presented especially here. One is Si microprobe electrode and tube array chips for recording of neurons in the tissue and drug deliver use. The probe array can be fabricated on IC chip, using standard IC process followed by a selective...
A fused pH and fluorescence sensor is proposed, and a prototype has been fabricated using CMOS silicon integrated circuit technology. Fluorescence intensity and pH can be detected at the same pixel for the first time. In the proposed device, a pH sensor which uses CCD image sensor technology and a filter-less fluorescence detection sensor are fused in the same pixel, enabling fluorescence and pH signals...
32times32 acetylcholine image sensors were successfully fabricated by using the CCD/CMOS image sensor technique, and real time imaging of acetylcholine distribution was carried out without label and a huge measurement. Acetylcholine imaging technology has a lot of potential for the early stage of Alzheimer's disease, the release mechanism between terminal neurons. In addition, the proposed sensor...
This research succeeded in capturing the behavior of potassium ion as moving image for the first time. A 2-dimensional potassium ion image sensor has been developed successfully. 32times32-pixels potassium ion image sensor was successfully fabricated by using CCD/CMOS image sensor technique and coating technology of organic responsive membranes. The sensor can take images of the concentration distribution...
32 x 32 pH image sensors were successfully fabricated by using the CCD/CMOS image sensor technique, and real time imaging of a chemical reaction and pH distribution was carried out for the first time. The pH variations by a chemical reaction are observed by 200 ms step (i.e. 5 flames per sec). The pH image sensor was able to take a pH image of mouse stomach successfully. It means that the novel image...
A differential input device was realised based on CCD technology. A set of two CCDs having two input gates connected inversely to each other represented the response analogous to that of the on-centre and off-centre units in biological systems, by combining the multiplier. Simple contrast edge detection can be realised using the differential input device.<<ETX>>
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