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Calpain3 (CAPN3, p94) is a muscle-specific nonlysosomal cysteine proteinase. Loss of proteolytic function or change of other properties of this enzyme (such as stability or ability to interact with other muscular proteins) is manifested as limb girdle muscular dystrophy type 2A (LGMD2A, calpainopathy). These pathological changes in properties of calpain3 are caused by mutations in the calpain3 gene...
The title compound 1 was prepared by sulfuric acid-catalyzed acetalation of d-xylose followed by partial hydrolysis with aqueous sodium carbonate added directly to a crude acetalation mixture. The yield of crystalline 1 (mp 42-43°C) was 80%.
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