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The effectiveness of prodrug-enhancer combination under in vivo skin penetration enhancement was studied using acyclovir and its lipophilic prodrugs, i.e. acyclovir valerate, isovalerate and pivarate together with an enhancer, 1-geranylazacycloheptan-2-one (GACH). Under in vivo penetration experiment with rat skin, we estimated absorption amounts of both prodrug and metabolized acyclovir respectively...