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An injection of 5% mustard in vegetable oil, an injection of vegetable oil and needle prick into a rat leg gastrocnemius muscle were selected as stressor stimuli. Expression of c-fos mRNA and interleukin-2 (IL-2) mRNA was measured using digoxigenin labeled cDNA probe. C-fos-like proteins were determined by an immunochemical method with anti-c-fos polyclonal antibodies. Thirty min after the injection...
Introduction: Bi-directional communications between the central nervous system (CNS) and the immune system may be realized also at the gene level. In the present investigations the regulatory action of low molecular nuclear proteins from rat splenic (SNE) or brain (BNE) cells on the interleukin-2 (IL-2) gene expression in normal conditions have been shown. Now we shall focus our attention on the stress...
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