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In this paper, we quantify spatial heterogeneity in the positions of live cells as potential biomarkers for cell viability in 3d in-vitro microenvironment under the impact of anti-cancer agents. We present three case studies using human colorectal cancer cell lines of HCT-116, SW-620 and SW-480 in 48-hour experiments. With our data acquisition system guiding an inverted microscope and a digital camera,...
Spatial properties of cell assays obtained by monitoring morphological characteristics of incubated cancer cells are studied as cell apoptosis indicators. Human colon carcinoma cells were cultured in 3d in-vitro microenvironment with FOLFOX treatment to experimentally evaluate cell viability for multiple days. With a 3D cell tracking algorithm guiding an inverted microscope in combination with a digital...
In evaluation of cell viability and apoptosis, spatial heterogeneity is quantified for cancerous cells cultured in 3-D in vitro cell-based assays under the impact of anti-cancer agents. In 48-h experiments using human colorectal cancer cell lines of HCT-116, SW-620, and SW-480, incubated cells are divided into control and drug administered groups, to be grown in matrigel and FOLFOX solution, respectively...
Heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) is an RNA-binding protein that modulates splice site usage, polyadenylation, and cleavage efficiency. This protein has also been implicated in mRNA stability and transport from the nucleus. We have previously demonstrated that hnRNP A1 had diminished protein levels and showed cytoplasmic accumulation in senescent human diploid fibroblasts. Furthermore,...
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