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Roxithromycin (ROX), a class IV drug has 50% absolute oral bioavailability due to poor aqueous solubility. The present study deals with exploring the effect of homogenization, homogenization followed by freeze drying and homogenization followed by spray drying in the presence of solubilizers on drug solubility and dissolution rate. Homogenization and subsequent freeze drying resulted in 3–4 fold increase...