Search results for: Qi Hua He

Items from 1 to 14 out of 14 results

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Proteotranscriptomic analyses of the midgut and Malpighian tubules after a sublethal concentration of Cry1Ab exposure on Spodoptera litura

Ya‐Jing Xu, Yu‐Ning Zhang, Xue‐Yang, Shao‐Peng Hao, more

Pest Management Science > 80 > 6 > 2587 - 2595

BACKGROUND Cry1Ab has emerged as a bio‐insecticide to control Spodoptera litura (Lepidoptera: Noctuidae). However, the sublethal effects of Cry1Ab on the physiological changes and molecular level of S. litura have not been well documented. Our aims in this study were to assess the sublethal effect of Cry1Ab on S. litura, including midgut and Malpighian tubules as targets. RESULTS After sublethal...

article

Disruption of endothelial barrier function is linked with hyposecretion and lymphocytic infiltration in salivary glands of Sjögren's syndrome

Xin Cong, Xue-Ming Zhang, Yan Zhang, Tai Wei, more

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease > 2018 > 1864 > 10 > 3154-3163

Sjögren's syndrome (SS) is an inflammatory autoimmune disease that causes hyposecretion in salivary glands. Endothelial tight junctions (TJs) play crucial roles in salivation and barrier function of blood vessels. However, whether the alteration of endothelial TJs were involved in pathogenesis of SS was still unknown. Here, the ultrastructure and function of endothelial TJs in submandibular glands...

article

A Minority Subpopulation of CD133⁺/EGFRvIII⁺/EGFR⁻ Cells Acquires Stemness and Contributes to Gefitinib Resistance

Xu‐Jie Liu, Wen‐Tao Wu, Wei‐Hua Wu, Feng Yin, more

CNS Neuroscience & Therapeutics > 19 > 7 > 494 - 502

AimsTo study the contribution of epidermal growth factor receptor variant III (EGFRvIII) to glioblastoma multiforme (GBM) stemness and gefitinib resistance. MethodsCD133⁺ and CD133⁻ cells were separated from EGFRvIII⁺ clinical specimens of three patients with newly diagnosed GBM. Then, RT‐PCR was performed to evaluate EGFRvIII and EGFR expression in CD133⁺ and CD133⁻ cells. The tumorigenicity and...

article

Lidamycin induces neural differentiation of mouse embryonic carcinoma cells through down-regulation of transcription factor Oct4

Hong-Ying Zhen, Qi-Hua He, Ying Li, Juan Zhou, more

Biochemical and Biophysical Research Communications > 2012 > 421 > 1 > 44-50

Lidamycin is a potential anti-cancer drug, which is widely used in a variety of human cancer types. It has been reported that lidamycin inhibited mouse embryonic carcinoma (EC) cells growth through down-regulation of embryonic stem (ES) cell-like genes. In this study, whether 0.01nM lidamycin induces neuronal differentiation of mouse EC cells was investigated. It was observed that lidamycin decreased...

article

Inhibition of mouse embryonic carcinoma cell growth by lidamycin through down-regulation of embryonic stem cell-like genes Oct4, Sox2 and Myc

Hong-Ying Zhen, Qi-Hua He, Yong-Zhan Zhen, Shu-Ling Wang, more

Investigational New Drugs > 2011 > 29 > 6 > 1188-1197

Summary Lidamycin (LDM, also known as C-1027) as an anti-cancer agent inhibits growth in a variety of cancer cells by inducing apoptosis and cell cycle arrest. In this study we demonstrated that inhibition of mouse embryonic carcinoma (EC) cell growth using LDM at low concentrations can be attributed to a loss of the cell’s self-renewal capability but not to apoptosis or cell death, which can be correlated...

article

Physiology and cell biology of acupuncture observed in calcium signaling activated by acoustic shear wave

Geng Li, Jie-Ming Liang, Pei-Wen Li, Xiaoqiang Yao, more

Pflügers Archiv - European Journal of Physiology > 2011 > 462 > 4 > 587-597

This article presents a novel model of acupuncture physiology based on cellular calcium activation by an acoustic shear wave (ASW) generated by the mechanical movement of the needle. An acupuncture needle was driven by a piezoelectric transducer at 100 Hz or below, and the ASW in human calf was imaged by magnetic resonance elastography. At the cell level, the ASW activated intracellular Ca²⁺ transients...

article

AGEs mediated expression and secretion of TNF alpha in rat retinal microglia

Ai Ling Wang, Albert C.H. Yu, Qi Hua He, Xiu'An Zhu, more

Experimental Eye Research > 2007 > 84 > 5 > 905-913

Diabetic retinopathy induces an inflammatory response in the retina characterized by an increase in inflammatory cytokines and the activation of microglia. The degree of microglia activation may influence the extent of retina injury following retinal metabolic stress. We have previously shown that DR rats have elevated levels of advanced glycation end products (AGEs) in their blood. We have also suggested...

article

The transport of α1A-adrenergic receptor with 33-nm step size in live cells

Zhang-Yi Liang, Ning Xu, Ying-Hua Guan, Ming Xu, more

Biochemical and Biophysical Research Communications > 2007 > 353 > 2 > 231-237

We used the technique of single particle tracking (SPT) with high tempo-spatial resolution to efficiently explore the route and mechanism for the transport of α _1A -adrenergic receptor (α _1A -AR) in real time in living cells. We found that the initial transport of α _1A -AR in cells depended on actin filaments with the velocity of 0.2μm/s and exhibited discrete 33-nm steps....

article

Up-regulation of the expression of cocaine and amphetamine-regulated transcript peptide by electroacupuncture in the arcuate nucleus of diet-induced obese rats

De-Run Tian, Xiao-Dong Li, Fei Wang, Dong-Bin Niu, more

Neuroscience Letters > 2005 > 383 > 1-2 > 17-21

It was reported that acupuncture or electro-acupuncture (EA) is effective in reducing the body weight for obese patients, although the mechanisms remain obscure. In a previous study, we have found that rats fed with high-fat (HIF) diet developed diet-induced obesity (DIO) with a concomitant decrease in the hypothalamic content of the cocaine and amphetamine-regulated transcript (CART) peptide, a peptide...

article

Triptolide protects dopaminergic neurons from inflammation-mediated damage induced by lipopolysaccharide intranigral injection

Hui-Fang Zhou, Xian-Yu Liu, Dong-Bin Niu, Feng-Qiao Li, more

Neurobiology of Disease > 2005 > 18 > 3 > 441-449

Converging lines of evidence suggest that neuroinflammatory processes may account for the progressive death of dopaminergic neurons in Parkinson's disease (PD). Therefore, anti-inflammatory strategies have attracted much interest for their potential to prevent further deterioration of PD. Our previous study showed that triptolide, a traditional Chinese herbal compound with anti-inflammatory and immunosuppressive...

article

Ganoderma total sterol (GS) and GS1 protect rat cerebral cortical neurons from hypoxia/reoxygenation injury

Hong-Bo Zhao, Sai-Zhen Wang, Qi-hua He, Lan Yuan, more

Life Sciences > 2005 > 76 > 9 > 1027-1037

The effect of Ganoderma total sterol (GS) and its main components(GS ₁ ) on rat cortical neuronal cultures exposed to hypoxia/reoxygenation (H/R) was studied in vitro. GS (0.01,0.1,1 μg/ml) increased neuron viability following H/R. GS also significantly reduced malondialdehyde content and reactive oxygen species production and increased manganese superoxide dismutase (Mn-SOD) activity; furthermore,...

article

Electro-acupuncture stimulation protects dopaminergic neurons from inflammation-mediated damage in medial forebrain bundle-transected rats

Xian-Yu Liu, Hui-Fang Zhou, Yan-Li Pan, Xi-Bin Liang, more

Experimental Neurology > 2004 > 189 > 1 > 189-196

Through producing a variety of cytotoxic factors upon activation, microglia are believed to participate in the mediation of neurodegeneration. Intervention against microglial activation may therefore exert a neuroprotective effect. Our previous study has shown that the electro-acupuncture (EA) stimulation at 100 Hz can protect axotomized dopaminergic neurons from degeneration. To explore the underlying...

article

Infusion of epidermal growth factor and basic fibroblast growth factor into the striatum of parkinsonian rats leads to in vitro proliferation and differentiation of adult neural progenitor cells

Kun Wang, Jian-Jun Wang, Yue Wang, Qi-Hua He, more

Neuroscience Letters > 2004 > 364 > 3 > 154-158

This study investigated the proliferation and differentiation of adult neural progenitor cells (aNPCs) derived from the striatum and substantia nigra (SN) of parkinsonian rats. We found that aNPCs isolated from the two areas of parkinsonian rats readily formed nestin-enriched neurospheres in vitro and exhibited an ability to differentiate into either neurons or astrocytes. Injection of epidermal growth...

article

Neurotrophic and Neuroprotective Effects of Tripchlorolide, an Extract of Chinese Herb Tripterygium wilfordii Hook F, on Dopaminergic Neurons

Feng-Qiao Li, Xiao-Xin Cheng, Xi-Bin Liang, Xin-Hong Wang, more

Experimental Neurology > 2003 > 179 > 1 > 28-37

It has been reported recently that the immunosuppressant FK506 produced neurotrophic and neuroprotective effects on dopaminergic neurons in vitro and in vivo. We investigated whether tripchlorolide, an immunosuppressive extract of Chinese herb Tripterygium wilfordii Hook F, could exert similar neurotrophic and neuroprotective effects similar to those of FK506. It was found that tripchlorolide promoted...

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