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Tau pathologically aggregates in Alzheimer's disease, and evidence suggests that reducing tau expression may be safe and beneficial for the prevention or treatment of this disease. We sought to examine the role of the 3′‐untranslated region (3′‐UTR) of human tau mRNA in regulating tau expression. Tau expresses two 3′‐UTR isoforms, long and short, as a result of alternative polyadenylation. Using luciferase...
J. Neurochem. (2012) 121, 763–773.
Abstractβ‐Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the transmembrane aspartyl protease that catalyzes the first cleavage step in the proteolysis of the APP to the amyloid β‐protein (Aβ), a process involved in the pathogenesis of Alzheimer disease. BACE1 pre‐mRNA undergoes complex alternative splicing, the regulation of which is not well...
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