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We report a case of adenocarcinoma of the lung that was strongly suggested to have produced alpha-fetoprotein (AFP). Sputum cytology and TBLB showed adenocarcinoma. Serum AFP was 230 ng/ml and the concentration of AFP in sputum was 120 ng/ml. Liver cirrhosis, hepatocellular carcinoma, carcinomas of gastrointestinal tract, mediastinal tumor and testicular tumor were excluded in the present case...