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To better understand Simian betaretrovirus (SRV) seropositivity in virus‐negative macaques, we transfused blood from SRV‐infected or suspect donors into immunosuppressed naive recipients. Our results do not support typical SRV1‐5 infection as the cause, but provide evidence for several possibilities including serological artifact, new/different SRV, or an endogenous virus.
Recently, RD114 (feline endogenous retrovirus envelope protein)-pseudotyped retroviral particles have been shown to transduce human NOD/SCID repopulating cells efficiently. In this study, we compared directly transduction of repopulating cells with RD114-pseudotyped vector to that with standard amphotropic vector in the rhesus macaque model. G-CSF/SCF-mobilized CD34 + rhesus peripheral blood...
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