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Early works leading to the detection of the pneumococcus and eventually to the appreciation that isolates differed in agglutination and that antisera differed in their capacity to protect against pneumococcal infection in the mouse protection test are reviewed. Studies by researchers from Europe, South Africa, and the United States over nearly five decades led to the introduction of serum therapy...
Splenectomized children as well as those suffering from nephrotic syndrome or recurrent asthmatic bronchitis have an increased susceptibility to systemic pneumococcal infections compared to healthy children. To determine the immunogenicity and safety of a 23-valent pneumococcal polysaccharide vaccine (PPV), 119 children (21 healthy, 26 splenectomized children, 48 with nephrotic syndrome and 24 with...
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