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Bromate (BrO 3− ) is a drinking water disinfection by-product (DBP) that induces renal cell death via DNA damage-dependent and -independent mechanisms. Drinking water contains other DBPs in addition to BrO 3− . We tested the effect of two of these, sodium chlorite (NaClO 2 ) and bromochloroacetic acid (BCAA), on BrO 3− cytotoxicity in normal rat kidney...
The mechanisms of bromate (BrO 3− )-induced toxicity in Normal Rat Kidney (NRK) and human embryonic kidney 293 (HEK293) cells were investigated. BrO 3− (added as KBrO 3 ) induced concentration-dependent decreases in 3-(4, dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) staining after 48h. BrO 3− -induced necrosis based on tandem increases in...
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