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Purpose
To investigate the effect of the analysis technique on estimating hepatic iron content using MRI.
Materials and Methods
We evaluated the influences of single‐exponential (EXP), bi‐exponential (BEXP), and exponential‐plus‐constant (CEXP) models; and pixel‐wise (MAP), average (AVG), and median (MED) signal calculation methods on T2* measurement using numerical simulations, calibrated phantoms,...
Iron toxicity is the major factor for tissue damage and organ failure in patients with iron overload. T2∗ measurement with magnetic resonance imaging (MRI) has been established as an effective and non-invasive technique for evaluating iron content in the liver. However, different factors related to the adopted image processing criterion affect the resulting measurements. These factors include the...
Iron toxicity is a key factor for tissue damage in iron-overloaded patients, with induced heart failure being the main cause of death. T2∗-weighted magnetic resonance imaging (MRI) has been established as the method of choice for evaluating iron content with strong correlation with biopsy, where T2∗ < 20 ms and T2∗ < 10 ms at 1.5T indicate iron overload and severe iron overload, respectively...
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