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The tumor suppressor gene p53 is a potent transcriptional regulator for genes involved in many cellular activities including cell cycle arrest and apoptosis. In this study, we examined the role of p53 in neuronal death induced by the sodium channel modulator veratridine. We also analyzed the involvement of Ca 2+ , mitochondria and reactive oxygen species in p53 activation. Exposure of...
In this paper, we show that exposure of chromaffin cells to high K + (75 mM) for 5 min releases about 15% of total norepinephrine and 8% of total epinephrine contained in chromaffin cells. The measured resting membrane potential of these cells was −55 mV. Long (10 s) depolarizing electrical pulses applied from a holding potential of −55 mV to 5 mV, that would produce a depolarization similar...
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