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Non‐technical summary Muscle function depends on tightly regulated Ca2+ movement between the intracellular sarcoplasmic reticulum (SR) Ca2+ store and cytoplasm in muscle cells. Disturbances in these processes have been linked to impaired muscle function and muscle disease. We disrupted the gene for the SERCA2 SR Ca2+ pump in mouse skeletal muscle to study how decreased transport of Ca2+ into the...
Sarco(endo)plasmic reticulum calcium ATPases (SERCA) are cellular pumps that transport Ca 2+ into the sarcoplasmic reticulum (SR). Serca2 is the most widely expressed gene family member. The very early embryonic lethality of Serca2 null mouse embryos has precluded further evaluation of loss of Serca2 function in the context of organ physiology. We have generated mice carrying a conditional...
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