Search results for: Yixian Zheng

Items from 1 to 20 out of 37 results

article

Cover Image

Alexander F. Chin, Yixian Zheng, Vincent J. Hilser

Fluorescence recovery after photobleaching of the BuGZ protein expressed in insect cells indicates the existence of liquid phase separation. See article by Chin et al., https://doi.org/10.1002/pro.4270.

article

Phylogenetic convergence of phase separation and mitotic function in the disordered protein BuGZ

Alexander F. Chin, Yixian Zheng, Vincent J. Hilser

Protein Science > 31 > 4 > 822 - 834

Intrinsically disordered proteins (IDPs) effect biological function despite their sequence‐encoded lack of preference for stable three‐dimensional structure. Among their many functions, IDPs form membraneless cellular compartments through liquid–liquid phase separation (LLPS), also termed biomolecular condensation. The extent to which LLPS has been evolutionarily selected remains largely unknown,...

article

S-to-P Conversions from Mid-mantle Slow Scatterers in Slab Regions: Observations of Deep/Stagnated Oceanic Crust?

Xiaobo He, Yixian Zheng

Pure and Applied Geophysics > 2018 > 175 > 6 > 2045-2055

The fate of a subducted slab is a key ingredient in the context of plate tectonics, yet it remains enigmatic especially in terms of its crustal component. In this study, our efforts are devoted to resolve slab-related structures in the mid-mantle below eastern Indonesia, the Izu–Bonin region, and the Peru area by employing seismic array analysing techniques on high-frequency waveform data from F-net...

chapter

MobiSeg: Interactive region segmentation using heterogeneous mobility data

Wenchao Wu, Yixian Zheng, Nan Cao, Haipeng Zeng, more

2017 IEEE Pacific Visualization Symposium (PacificVis) > 91 - 100

2017 IEEE Pacific Visualization Symposium (PacificVis)

With the acceleration of urbanization and modern civilization, more and more complex regions are formed in urban area. Although understanding these regions could provide huge insights to facilitate valuable applications for urban planning and business intelligence, few methods have been developed to effectively capture the rapid transformation of urban regions. In recent years, the widely applied...

article

VisMatchmaker: Cooperation of the User and the Computer in Centralized Matching Adjustment

Po-Ming Law, Wenchao Wu, Yixian Zheng, Huamin Qu

IEEE Transactions on Visualization and Computer Graphics > 2017 > 23 > 1 > 231 - 240

Centralized matching is a ubiquitous resource allocation problem. In a centralized matching problem, each agent has a preference list ranking the other agents and a central planner is responsible for matching the agents manually or with an algorithm. While algorithms can find a matching which optimizes some performance metrics, they are used as a black box and preclude the central planner from applying...

chapter

TelcoFlow: Visual exploration of collective behaviors based on telco data

Yixian Zheng, Wenchao Wu, Haipeng Zeng, Nan Cao, more

2016 IEEE International Conference on Big Data (Big Data) > 843 - 852

2016 IEEE International Conference on Big Data (Big Data)

Collective behavior is an important concept defined to capture behavioral patterns emerged among the crowd spontaneously. In social science, people's behaviors can be regarded as temporal transitions between a set of typical states (e.g., home and work) which are always associated with certain locations. This fact leads to an interesting research topic in developing ways to explore people's collective...

article

Visual Analytics in Urban Computing: An Overview

Yixian Zheng, Wenchao Wu, Yuanzhe Chen, Huamin Qu, more

IEEE Transactions on Big Data > 2016 > 2 > 3 > 276 - 296

Nowadays, various data collected in urban context provide unprecedented opportunities for building a smarter city through urban computing. However, due to heterogeneity, high complexity and large volumes of these urban data, analyzing them is not an easy task, which often requires integrating human perception in analytical process, triggering a broad use of visualization. In this survey, we first...

article

Lamin in inflammation and aging

Joseph R Tran, Haiyang Chen, Xiaobin Zheng, Yixian Zheng

Current Opinion in Cell Biology > 2016 > 40 > C > 124-130

Aging is characterized by a progressive loss of tissue function and an increased susceptibility to injury and disease. Many age-associated pathologies manifest an inflammatory component, and this has led to the speculation that aging is at least in part caused by some form of inflammation. However, whether or not inflammation is truly a cause of aging, or is a consequence of the aging process is unknown...

article

TelCoVis: Visual Exploration of Co-occurrence in Urban Human Mobility Based on Telco Data

Wenchao Wu, Jiayi Xu, Haipeng Zeng, Yixian Zheng, more

IEEE Transactions on Visualization and Computer Graphics > 2016 > 22 > 1 > 935 - 944

Understanding co-occurrence in urban human mobility (i.e. people from two regions visit an urban place during the same time span) is of great value in a variety of applications, such as urban planning, business intelligence, social behavior analysis, as well as containing contagious diseases. In recent years, the widespread use of mobile phones brings an unprecedented opportunity to capture large-scale...

article

Low-Cell-Number Epigenome Profiling Aids the Study of Lens Aging and Hematopoiesis

Xiaobin Zheng, Sibiao Yue, Haiyang Chen, Blake Weber, more

Cell Reports > 2015 > 13 > 7 > 1505-1518

Understanding how chromatin modification regulates development and disease can be limited by available material. Despite recent progress, balancing high-quality and reliable mapping using chromatin-immunoprecipitation-based deep sequencing (ChIP-seq) remains a challenge. We report two techniques, recovery via protection (RP)-ChIP-seq and favored amplification RP-ChIP-seq (FARP-ChIP-seq), that provide...

chapter

Visual analysis of bi-directional movement behavior

Yixian Zheng, Wenchao Wu, Huamin Qu, Chunyan Ma, more

2015 IEEE International Conference on Big Data (Big Data) > 581 - 590

2015 IEEE International Conference on Big Data (Big Data)

The availability of massive volumes of trajectory data has made it convenient for the study of different types of movement behaviors. Among them, bi-directional movement behaviors exist ubiquitously in our daily life, from urban traffic to animal migration, and from sports to wars. To analyze bi-directional movement behaviors, people need to compare movements in two directions simultaneously for detecting...

article

Phase Transition of Spindle-Associated Protein Regulate Spindle Apparatus Assembly

Hao Jiang, Shusheng Wang, Yuejia Huang, Xiaonan He, more

Cell > 2015 > 163 > 1 > 108-122

Spindle assembly required during mitosis depends on microtubule polymerization. We demonstrate that the evolutionarily conserved low-complexity protein, BuGZ, undergoes phase transition or coacervation to promote assembly of both spindles and their associated components. BuGZ forms temperature-dependent liquid droplets alone or on microtubules in physiological buffers. Coacervation in vitro or in...

article

Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

Haiyang Chen, Xiaobin Zheng, Yixian Zheng

Cell > 2015 > 163 > 1 > 256-257

article

Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

Haiyang Chen, Xiaobin Zheng, Yixian Zheng

Cell > 2014 > 159 > 4 > 829-843

Aging of immune organs, termed as immunosenescence, is suspected to promote systemic inflammation and age-associated disease. The cause of immunosenescence and how it promotes disease, however, has remained unclear. We report that the Drosophila fat body, a major immune organ, undergoes immunosenescence and mounts strong systemic inflammation that leads to deregulation of immune deficiency (IMD) signaling...

chapter

BoundarySeer: Visual analysis of 2D boundary changes

Wenchao Wu, Yixian Zheng, Huamin Qu, Wei Chen, more

2014 IEEE Conference on Visual Analytics Science and Technology (VAST) > 143 - 152

2014 IEEE Conference on Visual Analytics Science and Technology (VAST)

Boundary changes exist ubiquitously in our daily life. From the Antarctic ozone hole to the land desertification, and from the territory of a country to the area within one-hour reach from a downtown location, boundaries change over time. With a large number of time-varying boundaries recorded, people often need to analyze the changes, detect their similarities or differences, and find out spatial...

article

A Microtubule-Associated Zinc Finger Protein, BuGZ, Regulates Mitotic Chromosome Alignment by Ensuring Bub3 Stability and Kinetochore Targeting

Hao Jiang, Xiaonan He, Shusheng Wang, Junling Jia, more

Developmental Cell > 2014 > 28 > 3 > 268-281

Equal chromosome segregation requires proper assembly of many proteins, including Bub3, onto kinetochores to promote kinetochore-microtubule interactions. By screening for mitotic regulators in the spindle envelope and matrix (Spemix), we identify a conserved Bub3 interacting and GLE-2-binding sequence (GLEBS) containing ZNF207 (BuGZ) that associates with spindle microtubules and regulates chromosome...

article

Sculpting the Nucleus with Dynamic Microtubules

Yuxuan Guo, Yixian Zheng

Developmental Cell > 2013 > 27 > 1 > 1-2

How nuclear morphology is regulated during development and disease remains poorly understood. In this issue of Developmental Cell, using a pronuclear assembly assay, Xue et al. (2013) demonstrate that Dppa2, a chromatin-bound microtubule regulator, controls both the morphology and function of the pronucleus by fine-tuning microtubule dynamics.

article

Generation and characterization of a conditional deletion allele for Lmna in mice

Youngjo Kim, Yixian Zheng

Biochemical and Biophysical Research Communications > 2013 > 440 > 1 > 8-13

Extensive efforts have been devoted to study A-type lamins because mutations in their gene, LMNA in humans, are associated with a number of diseases. The mouse germline mutations in the A-type lamins (encoded by Lmna) exhibit postnatal lethality at either 4–8 postnatal (P) weeks or P16–18days, depending on the deletion alleles. These mice exhibit defects in several tissues including hearts and skeletal...

article

The Nuclear Lamina Regulates Germline Stem Cell Niche Organization via Modulation of EGFR Signaling

Haiyang Chen, Xin Chen, Yixian Zheng

Cell Stem Cell > 2013 > 13 > 1 > 73-86

Stem cell niche interactions have been studied extensively with regard to cell polarity and extracellular signaling. Less is known about the way in which signals and polarity cues integrate with intracellular structures to ensure appropriate niche organization and function. Here, we report that nuclear lamins function in the cyst stem cells (CySCs) of Drosophila testes to control the interaction of...

article

Nucleating New Branches from Old

Yixian Zheng, Pablo A. Iglesias

Cell > 2013 > 152 > 4 > 669-670

Centrosome- and chromatin-based microtubule nucleation pathways have been implicated in spindle assembly. Using total internal reflection fluorescent microscopy and Xenopus egg extracts, Petry et al. demonstrate that new microtubules can also nucleate and branch out from existing ones in animal cells.

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INFONA - science communication portal

Search results for: Yixian Zheng

Cover Image

Phylogenetic convergence of phase separation and mitotic function in the disordered protein BuGZ

S-to-P Conversions from Mid-mantle Slow Scatterers in Slab Regions: Observations of Deep/Stagnated Oceanic Crust?

MobiSeg: Interactive region segmentation using heterogeneous mobility data

VisMatchmaker: Cooperation of the User and the Computer in Centralized Matching Adjustment

TelcoFlow: Visual exploration of collective behaviors based on telco data

Visual Analytics in Urban Computing: An Overview

Lamin in inflammation and aging

TelCoVis: Visual Exploration of Co-occurrence in Urban Human Mobility Based on Telco Data

Low-Cell-Number Epigenome Profiling Aids the Study of Lens Aging and Hematopoiesis

Visual analysis of bi-directional movement behavior

Phase Transition of Spindle-Associated Protein Regulate Spindle Apparatus Assembly

Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

Age-Associated Loss of Lamin-B Leads to Systemic Inflammation and Gut Hyperplasia

BoundarySeer: Visual analysis of 2D boundary changes

A Microtubule-Associated Zinc Finger Protein, BuGZ, Regulates Mitotic Chromosome Alignment by Ensuring Bub3 Stability and Kinetochore Targeting

Sculpting the Nucleus with Dynamic Microtubules

Generation and characterization of a conditional deletion allele for Lmna in mice

The Nuclear Lamina Regulates Germline Stem Cell Niche Organization via Modulation of EGFR Signaling

Nucleating New Branches from Old

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