Wyniki wyszukiwania dla: Robert D. Henderson

Pozycje od 1 do 20 spośród 42 wyników

Poprzednia

Następna

artykuł

Verbal and nonverbal fluency in amyotrophic lateral sclerosis

Megan S. Barker, Amelia Ceslis, Rosemary Argall, Pamela McCombe, więcej

Journal of Neuropsychology > 18 > 2 > 265 - 285

Amyotrophic lateral sclerosis (ALS) is a multi‐system disorder that commonly affects cognition and behaviour. Verbal fluency impairments are consistently reported in ALS patients, and we aimed to investigate whether this deficit extends beyond the verbal domain. We further aimed to determine whether deficits are underpinned by a primary intrinsic response generation impairment (i.e., a global reduction...

artykuł

Associations of postprandial ghrelin, liver‐expressed antimicrobial peptide 2 and leptin levels with body composition, disease progression and survival in patients with amyotrophic lateral sclerosis

Stephanie L. Howe, Cory J. Holdom, Pamela A. McCombe, Robert D. Henderson, więcej

European Journal of Neurology > 31 > 1 > n/a - n/a

Background and purpose Loss of appetite contributes to weight loss and faster disease progression in amyotrophic lateral sclerosis (ALS). Impairment of appetite control in ALS may include altered production or action of orexigenic (i.e., ghrelin) and anorexigenic (i.e., liver‐expressed antimicrobial peptide 2 [LEAP2] and leptin) hormones. We aimed to determine if postprandial circulating ghrelin...

artykuł

Longitudinal changes in intrinsic motoneuron excitability in amyotrophic lateral sclerosis are dependent on disease progression

Gabriel S. Trajano, Lucas B. R. Orssatto, Pamela A. McCombe, Warwick Rivlin, więcej

The Journal of Physiology > 601 > 21 > 4723 - 4735

Abstract Increased amplitude of persistent inward currents (PICs) is observed in pre‐symptomatic genetically modified SOD1 mice models of amyotrophic lateral sclerosis (ALS). However, at the symptomatic stage this reverses and there is a large reduction in PIC amplitude. It remains unclear whether these changes in PICs can be observed in humans, with cross‐sectional studies in humans reporting contradictory...

artykuł

Clinical and neurophysiological biomarkers of disease progression in amyotrophic lateral sclerosis

Andrew Hannaford, Karen Byth, Nathan Pavey, Robert D. Henderson, więcej

Muscle & Nerve > 67 > 1 > 17 - 24

Introduction/Aims Rate of disease progression (ΔFS), measured as change in the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS‐R) and body mass index (BMI), are predictors of survival in amyotrophic lateral sclerosis (ALS). Our aim in this study was to assess the utility of these clinical biomarkers along with neurophysiological measures, such as the split hand index (SI), in...

artykuł

Lower hypothalamic volume with lower body mass index is associated with shorter survival in patients with amyotrophic lateral sclerosis

Jeryn Chang, Thomas B. Shaw, Cory J. Holdom, Pamela A. McCombe, więcej

European Journal of Neurology > 30 > 1 > 57 - 68

Background and purpose Weight loss in patients with amyotrophic lateral sclerosis (ALS) is associated with faster disease progression and shorter survival. Decreased hypothalamic volume is proposed to contribute to weight loss due to loss of appetite and/or hypermetabolism. We aimed to investigate the relationship between hypothalamic volume and body mass index (BMI) in ALS and Alzheimer's disease...

artykuł

Venous creatinine as a biomarker for loss of fat‐free mass and disease progression in patients with amyotrophic lateral sclerosis

Cory J. Holdom, Mark R. Janse van Mantgem, Ruben P. A. Eijk, Stephanie L. Howe, więcej

European Journal of Neurology > 28 > 11 > 3615 - 3625

Background and purpose To establish the utility of venous creatinine as a biomarker to monitor loss of fat‐free mass in patients with amyotrophic lateral sclerosis (ALS). Methods In this multicenter natural history study, body composition and venous creatinine were assessed in 107 patients with ALS and 52 healthy controls. Longitudinal patterns of venous creatinine and its association with the...

artykuł

Ghrelin as a treatment for amyotrophic lateral sclerosis

Shyuan T. Ngo, Hao Wang, Robert D. Henderson, Cyril Bowers, więcej

Journal of Neuroendocrinology > 33 > 7 > n/a - n/a

Ghrelin is a gut hormone best known for its role in regulating appetite and stimulating the secretion of the anabolic hormone growth hormone (GH). However, there is considerable evidence to show wider‐ranging biological actions of ghrelin that favour improvements in cellular and systemic metabolism, as well as neuroprotection. Activation of these ghrelin‐mediated pathways may alleviate pathogenic...

artykuł

Clinical and electrophysiological examination of pinch strength in patients with amyotrophic lateral sclerosis

John D. Lee, Saman Heshmat, Susan Heggie, Kathryn A. Thorpe, więcej

Muscle & Nerve > 63 > 1 > 108 - 113

Background The split‐hand concept has highlighted the preferential wasting of the thenar side of the hand in amyotrophic lateral sclerosis (ALS). Our objective is to re‐explore pinch grip strength to assess whether it has the potential to be a practical biomarker of ALS. Methods We measured different pinch grip strengths (thumb, index, and fifth) using a pinch gauge from both hands of 54 ALS patients...

artykuł

Tract integrity in amyotrophic lateral sclerosis: 6–month evaluation using MR diffusion tensor imaging

Ashwag R. Alruwaili, Kerstin Pannek, Robert D. Henderson, Marcus Gray, więcej

BMC Medical Imaging > 2019 > 19 > 1 > 1-10

Background This study was performed to assess changes in diffusion tensor imaging (DTI) over time in patients with amyotrophic lateral sclerosis (ALS). Methods We performed DTI in 23 ALS patients who had two magnetic resonance imaging (MRI) scans at 6 month intervals and to correlate results with clinical features. The revised ALS functional rating scale (ALSFRS–R) was administered at each clinical...

artykuł

The utility of FDG‐PET in complex neurological conditions

Zara A. Ioannides, Paul Thomas, Daman Langguth, Paul Kubler, więcej

Internal Medicine Journal > 47 > 12 > 1460 - 1462

artykuł

Peripheral nerve diffusion tensor imaging as a measure of disease progression in ALS

Neil G. Simon, Jim Lagopoulos, Sita Paling, Casey Pfluger, więcej

Journal of Neurology > 2017 > 264 > 5 > 882-890

Clinical trial design in amyotrophic lateral sclerosis (ALS) remains hampered by a lack of reliable and sensitive biomarkers of disease progression. The present study evaluated peripheral nerve diffusion tensor imaging (DTI) as a surrogate marker of axonal degeneration in ALS. Longitudinal studies were undertaken in 21 ALS patients studied at 0 and 3 months, and 19 patients at 0, 3 and 6 months, with...

artykuł

Family carers' experiences of receiving the news of a diagnosis of Motor Neurone Disease: A national survey

Samar M Aoun, Lauren J Breen, David Oliver, Robert D Henderson, więcej

Journal of the Neurological Sciences > 2017 > 372 > C > 144-151

Family carers have a central role in the care and support of people with MND and face the challenges of the disease from diagnosis to progression and the multiple losses of MND, but their support needs are often neglected.This study aimed to investigate the experiences of family carers at the time of diagnosis and their satisfaction with receiving the news. An anonymous postal survey was facilitated...

artykuł

Assessment of Motor Units in Neuromuscular Disease

Robert D. Henderson, Pamela A. McCombe

Neurotherapeutics > 2017 > 14 > 1 > 69-77

The motor unit comprises the anterior horn cell, its axon, and the muscle fibers that it innervates. Although the true number of motor units is unknown, the number of motor units appears to vary greatly between different muscles and between different individuals. Assessment of the number and function of motor units is needed in diseases of the anterior horn cell and other motor nerve disorders. Amyotrophic...

artykuł

Breaking the news of a diagnosis of motor neurone disease: A national survey of neurologists' perspectives

Samar M. Aoun, Lauren J. Breen, Robert Edis, Robert D. Henderson, więcej

Journal of the Neurological Sciences > 2016 > 367 > C > 368-374

Communication of the diagnosis of MND is daunting for patients and neurologists. This study aimed to establish a knowledge base of current Australian practice of breaking the news of an MND diagnosis, to assess the neurologists' educational and training needs and to compare the feedback obtained from neurologists and patients to international practice guidelines. An anonymous survey of neurologists...

artykuł

Dissociated lower limb muscle involvement in amyotrophic lateral sclerosis

Neil G. Simon, Michael Lee, Jong Seok Bae, Eneida Mioshi, więcej

Journal of Neurology > 2015 > 262 > 6 > 1424-1432

It has been suggested that corticomotoneuronal drive to ankle dorsiflexors is greater than to ankle plantar flexor muscles, despite the finding that plantar flexors are no less active than TA during walking and standing. The present study was undertaken to determine whether there was differential involvement of distal lower limb muscles in amyotrophic lateral sclerosis (ALS), to elucidate pathophysiological...

artykuł

Exposing asymmetric gray matter vulnerability in amyotrophic lateral sclerosis

Matthew S. Devine, Kerstin Pannek, Alan Coulthard, Pamela A. McCombe, więcej

NeuroImage: Clinical > 2015 > 7 > C > 782-787

Limb weakness in amyotrophic lateral sclerosis (ALS) is typically asymmetric. Previous studies have identified an effect of limb dominance on onset and spread of weakness, however relative atrophy of dominant and non-dominant brain regions has not been investigated. Our objective was to use voxel-based morphometry (VBM) to explore gray matter (GM) asymmetry in ALS, in the context of limb dominance...

artykuł

Vertebrobasilar dissections: Case series comparing patients with and without dissecting aneurysms

Monica S. Badve, Robert D. Henderson, John D. O’Sullivan, Andrew A. Wong, więcej

Journal of Clinical Neuroscience > 2014 > 21 > 11 > 2028-2030

Vertebrobasilar dissections are being increasingly diagnosed due to better awareness and increased availability of modern imaging techniques of the intracranial and extracranial arteries. The clinical presentation and outcome in patients with vertebrobasilar dissections may be complicated by dissecting aneurysms. The aim of this retrospective study was to compare the clinical profile of patients with...

artykuł

Marginal reversible jump Markov chain Monte Carlo with application to motor unit number estimation

Christopher C. Drovandi, Anthony N. Pettitt, Robert D. Henderson, Pamela A. McCombe

Computational Statistics and Data Analysis > 2014 > 72 > Complete > 128-146

Motor unit number estimation (MUNE) is a method which aims to provide a quantitative indicator of progression of diseases that lead to a loss of motor units, such as motor neurone disease. However the development of a reliable, repeatable and fast real-time MUNE method has proved elusive hitherto. Previously, a reversible jump Markov chain Monte Carlo (RJMCMC) algorithm has been implemented to produce...

artykuł

Progressive brainstem deficits in an immunosuppressed patient

Paul R. Chapman, Caroline A. Airey, Robert D. Henderson

Journal of Clinical Neuroscience > 2013 > 20 > 1 > 140

artykuł

Progressive brainstem deficits in an immunosuppressed patient

Paul R. Chapman, Caroline A. Airey, Robert D. Henderson

Journal of Clinical Neuroscience > 2013 > 20 > 1 > 190

Poprzednia

Następna

Opcje filtrowania

Data publikacji

Ostatni rok (2)
Ostatnie 3 lata (5)

Zamknij

Ustawianie zakresu dat

Podaj zakres dat dla filtrowania wyświetlonych wyników. Możesz podać datę początkową, końcową lub obie daty. Daty możesz wpisać ręcznie lub wybrać za pomocą kalendarza.

Od:

Do:
Ustaw własny zakres dat

INFONA - portal komunikacji naukowej

Wyniki wyszukiwania dla: Robert D. Henderson

Dodaj adresata

Anulowanie wysłania wiadomości

Czy na pewno chcesz anulować wysłanie wiadomości?

Wyślij wiadomość

Opcje filtrowania

Data publikacji

Ustawianie zakresu dat

Podaj zakres dat dla filtrowania wyświetlonych wyników. Możesz podać datę początkową, końcową lub obie daty. Daty możesz wpisać ręcznie lub wybrać za pomocą kalendarza.

Słowa kluczowe

Zbiór danych

Czasopismo

Zgłaszanie błędu / nadużycia

Nieudane wysłanie zgłoszenia

Ułatwienia dostępu