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Nous rapportons 2 cas survenus en 2016 au CHU de Caen où la fiabilité de l’épreuve globulaire de compatibilité (EGC), « dernier verrou de l’incompatibilité ABO » a été en défaut : cas 1 : à la suite de la transfusion au bloc des urgences de 14 concentrés de globules rouges O, 12 plasmas AB et 3 concentrés de plaquettes, en moins de 4heures en contexte d’urgence vitale, à un patient polytraumatisé...