Search results for: Brent Kelly

Items from 1 to 15 out of 15 results

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Toxic epidermal necrolysis and Stevens‐Johnson syndrome/toxic epidermal necrolysis overlap in pediatric patients with a focus on newer antiepileptic drugs: A 25‐year retrospective study at a single tertiary care center

Kristyna L. Gleghorn, Charles Voigt, Brent Kelly

Pediatric Dermatology > 38 > 4 > 812 - 818

Background Stevens‐Johnson syndrome (SJS) and toxic epidermal necrolysis Syndrome (TEN) are rare immune‐mediated diseases. Extensive research on adult triggers of SJS and TEN is available; however, research in children is more limited. Objective We sought to investigate and report the experience with pediatric SJS and TEN in our center, identifying associated medications. Methods A retrospective...

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Nephrogenic systemic fibrosis: A 15-year retrospective study at a single tertiary care center

Janice Wilson, Kristyna Gleghorn, Quincy Seigel, Brent Kelly

Journal of the American Academy of Dermatology > 2017 > 77 > 2 > 235-240

Despite multiple therapeutic approaches for nephrogenic systemic fibrosis (NSF), no single treatment has convincingly shown consistent benefit. The most successful outcomes have been associated with recovery of renal function, although evidence remains limited and past studies have been inconclusive.We sought to investigate whether improvement of renal function via successful transplantation or via...

article

Cryptococcoid Sweet's syndrome: Two reports of Sweet's syndrome mimicking cutaneous cryptococcosis

Janice Wilson, Kristyna Gleghorn, Brent Kelly

Journal of Cutaneous Pathology > 44 > 5 > 413 - 419

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Tzanck smear for quick screening of transient myeloproliferative disorder in neonates with vesiculopapular eruptions

Trisha Patel, Anisha B. Patel, Megan Moody, Brent Kelly, more

International Journal of Dermatology > 54 > 7 > e251 - e253

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Dual role of p53 amyloid formation in cancer; loss of function and gain of toxicity

Cristian A. Lasagna-Reeves, Audra L. Clos, Diana Castillo-Carranza, Urmi Sengupta, more

Biochemical and Biophysical Research Communications > 2013 > 430 > 3 > 963-968

The tumor suppressor p53 plays an important role in genome integrity. It is frequently mutated in all types of human cancers, making p53 a key factor in cancer progression. Two phenotypic consequences of these alterations are dominant; a loss of function and a gain of function of p53, which, in several cases, accumulates in intracellular aggregates. Although the nature of such aggregates is still...

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Etiology and Therapeutic Management of Erythema Nodosum During Pregnancy: An Update

K. Alexandra Acosta, Mary Claire Haver, Brent Kelly

American Journal of Clinical Dermatology > 2013 > 14 > 3 > 215-222

Erythema nodosum (EN) is the most common form of panniculitis. It is characterized by erythematous, raised, tender nodules that usually occur bilaterally on the extensor surfaces of the lower extremities. EN is associated with many underlying conditions including infection, sarcoidosis, malignancy, and pregnancy. Its underlying etiology, however, is unknown in up to half of cases. Pregnancy is thought...

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Predictive value of margins in diagnostic biopsies of nonmelanoma skin cancers

Julie E. Jackson, Brent Kelly, Matthew Petitt, Tatsuo Uchida, more

Journal of the American Academy of Dermatology > 2012 > 67 > 1 > 122-127

With geographic regional variation, nonmelanoma skin cancer biopsy reports include assessment of margins. When margins are reported as negative, clinical dilemmas may emerge concerning the necessity of additional treatment.To evaluate the predictive value of biopsy margins with regard to residual tumor present in subsequent excisions of nonmelanoma skin cancers.This is a retrospective review of 235...

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Erratum to: Urticaria: a review

Tasneem Poonawalla, Brent Kelly

American Journal of Clinical Dermatology > 2012 > 13 > 3 > 215-215

An Erratum for this chapter can be found at http://dx.doi.org/10.2165/0128071-200910010-00002

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Role of oligomers in the amyloidogenesis of primary cutaneous amyloidosis

Audra L. Clos, Cristian A. Lasagna-Reeves, Brent Kelly, Richard Wagner, more

Journal of the American Academy of Dermatology > 2011 > 65 > 5 > 1023-1031

Primary cutaneous amyloidosis (PCA) describes a heterogeneous group of cutaneous diseases characterized by amyloid deposition; this may manifest as macules, papules, or nodules, depending on the subtype involved. To date, relatively little is known about the process of amyloidogenesis in the skin; however, investigators recently have identified small amyloid species, known as oligomers, which give...

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Therapeutic removal of amyloid deposits in cutaneous amyloidosis by localised intra‐lesional injections of anti‐amyloid antibodies

Audra L. Clos, Cristian A. Lasagna‐Reeves, Richard Wagner, Brent Kelly, more

Experimental Dermatology > 19 > 10 > 904 - 911

Please cite this paper as: Therapeutic removal of amyloid deposits in cutaneous amyloidosis by localised intra‐lesional injections of anti‐amyloid antibodies. Experimental Dermatology 2010; 19: 904–911. Abstract: In the skin, amyloidosis can be found with or without systemic disease. Primary cutaneous amyloidosis defines those amyloidoses restricted to the skin without involvement of other systems...

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Lymphatic invasion detected by D2-40/S-100 dual immunohistochemistry does not predict sentinel lymph node status in melanoma

Matthew Petitt, Ashley Allison, Tally Shimoni, Tatsuo Uchida, more

Journal of the American Academy of Dermatology > 2009 > 61 > 5 > 819-828

Sentinel lymph node biopsy provides important prognostic information with controversial therapeutic advantages. D2-40 is a novel immunohistochemical stain specific for lymphatic endothelium often utilized to study tumor lymphangiogenesis and lymphatic invasion.To increase the detection of lymphatic invasion in primary cutaneous melanomas with D2-40/S-100 dual immunohistochemistry, and then apply the...

article

Urticaria

Tasneem Poonawalla, Brent Kelly

American Journal of Clinical Dermatology > 2009 > 10 > 1 > 9-21

Urticaria is often classified as acute, chronic, or physical based on duration of symptoms and the presence or absence of inducing stimuli. Urticarial vasculitis, contact urticaria, and special syndromes are also included under the broad heading of urticaria. Recent advances in our understanding of the pathogenesis of chronic urticaria include the finding of autoantibodies to mast cell receptors in...

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Nephrogenic systemic fibrosis is associated with transforming growth factor β and Smad without evidence of renin-angiotensin system involvement

Brent Kelly, Matthew Petitt, Ramon Sanchez

Journal of the American Academy of Dermatology > 2008 > 58 > 6 > 1025-1030

The mechanisms of fibrosis associated with nephrogenic systemic fibrosis (NSF) are largely unknown. Transforming growth factor beta (TGF-β), a known profibrotic cytokine, is theorized to play a central role. The renin-angiotensin system has been linked with both TGF-β expression and fibrosis in other organ systems.We sought to investigate whether these mechanisms were involved with NSF.Eleven biopsy...

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Secondary hypertrophic osteoarthropathy associated with solitary fibrous tumor of the lung

Julie Fridlington, Jason Weaver, Brent Kelly, Erica Kelly

Journal of the American Academy of Dermatology > 2007 > 57 > 5 Supplement > S106-S110

Secondary hypertrophic osteoarthropathy, synonymous with the terms “pulmonary hypertrophic osteoarthropathy” and “pachydermoperiostosis acquisita,” is a syndrome characterized by finger clubbing, hypertrophic skin changes, and periosteal bone changes that can occur in patients with underlying disease of the cardiovascular and pulmonary systems. We report the case of a 56-year-old man with a solitary...

article

O4-02-08 A tale of two statins: the effects of lovastatin and simvastatin on APP metabolism

Sarah L. Cole, Aneta Grudzien, Ingrid Manhart, Brent Kelly, more

Neurobiology of Aging > 2004 > 25 > Supplement 2 > S77

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