Search results for: Taro Sakamoto

Items from 1 to 20 out of 30 results

article

Blood loss in laparoscopic distal pancreatectomy could be underestimated

Norimitsu Okui, Kenei Furukawa, Tomohiko Taniai, Koichiro Haruki, more

Journal of Hepato‐Biliary‐Pancreatic Sciences > 30 > 7 > 962 - 969

Background Previous studies have reported that laparoscopic distal pancreatectomy (LDP) has an advantage in reducing blood loss over open distal pancreatectomy (ODP). This study was performed to investigate whether blood loss is truly reduced in LDP. Methods A total of 113 patients undergoing DP from 2014 to 2022 were classified into Open and LDP groups and compared by statistical analysis. Estimated...

article

A collaborative workflow between pathologists and deep learning for the evaluation of tumour cellularity in lung adenocarcinoma

Taro Sakamoto, Tomoi Furukawa, Hoa H N Pham, Kishio Kuroda, more

Histopathology > 81 > 6 > 758 - 769

Aims The reporting of tumour cellularity in cancer samples has become a mandatory task for pathologists. However, the estimation of tumour cellularity is often inaccurate. Therefore, we propose a collaborative workflow between pathologists and artificial intelligence (AI) models to evaluate tumour cellularity in lung cancer samples and propose a protocol to apply it to routine practice. Methods...

article

Incidental abdominal lymph node metastases from a known breast cancer in resected specimen of invasive pancreatic ductal adenocarcinoma: report of a case

Tomohiko Taniai, Koichiro Haruki, Michinori Matsumoto, Taro Sakamoto, more

International Cancer Conference Journal > 2019 > 8 > 4 > 190-194

Breast cancer is known to metastasize to all organs of the body. However, abdominal lymph node metastases from breast cancer are extremely rare. We herein report a resected case of an invasive pancreatic ductal adenocarcinoma (PDAC) in which abdominal lymph node metastases from breast cancer were diagnosed. A 54-year-old woman was pointed out to have a tumor in the pancreatic tail with dilatation...

article

Radical resection of an initially unresectable intrahepatic cholangiocarcinoma after chemotherapy with using gemcitabine, cisplatin, and S-1: report of a case

Masashi Tsunematsu, Koichiro Haruki, Taro Sakamoto, Tadashi Uwagawa, more

Surgical Case Reports > 2019 > 5 > 1 > 1-4

Background Metastatic biliary tract cancer (BTC) has poor prognosis. Recently, patients with metastatic BTC who respond well to systemic chemotherapy can be treated by radical resection or “conversion surgery.” Case presentation A 67-year-old male patient was diagnosed with intrahepatic cholangiocarcinoma with para-aortic metastases [cT2N1M1, stage IVB]. He was enrolled in our phase II study for...

article

Secreted d‐aspartate oxidase functions in C. elegans reproduction and development

Yasuaki Saitoh, Masumi Katane, Tetsuya Miyamoto, Masae Sekine, more

The FEBS Journal > 286 > 1 > 124 - 138

d‐Aspartate oxidase (DDO) is a degradative enzyme that acts stereospecifically on free acidic D‐amino acids such as d‐aspartate and d‐glutamate. d‐Aspartate plays an important role in regulating neurotransmission, developmental processes, hormone secretion, and reproductive functions in mammals. In contrast, the physiological role of d‐glutamate in mammals remains unclear. In Caenorhabditis elegans...

article

Risk stratification using a novel liver functional reserve score of combination prothrombin time–international normalized ratio to albumin ratio and albumin in patients with hepatocellular carcinoma

Koichiro Haruki, Hiroaki Shiba, Nobuhiro Saito, Takashi Horiuchi, more

Surgery > 2018 > 164 > 3 > 404-410

Liver function in patients with hepatocellular carcinoma is generally graded according to the Child-Pugh system; however, some variables in the Child-Pugh grade are subjective. We developed a novel, objective score called the prothrombin time–international normalized ratio to albumin ratio. The aim of this study was to evaluate the prognostic value of this new score in patients with hepatocellular...

article

Laparoscopic fenestration for a huge symptomatic splenic cyst in a patient with Gaucher’s disease

Kyohei Abe, Hiroaki Shiba, Junichi Shimada, Shinji Onda, more

Clinical Journal of Gastroenterology > 2018 > 11 > 3 > 217-219

A 34-year-old woman visited our hospital for treatment of a huge splenic cyst with epigastric pain. She had been diagnosed with Gaucher’s disease (Type 1) at 3 years of age and had been receiving enzyme replacement therapy (ERT) from 15 years of age. Abdominal MRI showed a low-intensity area, 30 cm in diameter, with a well-defined border on T1-weighted images. The patient underwent laparoscopic fenestration...

article

Repeated Clostridium difficile infection after living donor liver transplantation

Kyohei Abe, Hiroaki Shiba, Kenei Furukawa, Taro Sakamoto, more

Clinical Journal of Gastroenterology > 2018 > 11 > 4 > 309-311

Liver transplant recipients are considered to be at high risk for Clostridium difficile infection, with an incidence of 2.7–8.0%, which is three times higher than that among other patients. A case of a patient who suffered from pseudomembranous colitis five times after living donor liver transplantation is reported. A 60-year-old woman underwent splenectomy and living donor liver transplantation using...

article

Impact of the C-reactive protein to albumin ratio on long-term outcomes after hepatic resection for colorectal liver metastases

Koichiro Haruki, Hiroaki Shiba, Takashi Horiuchi, Taro Sakamoto, more

The American Journal of Surgery > 2017 > 214 > 4 > 752-756

The aim of this study is to investigate the association C-reactive protein to albumin (CRP/Alb) ratio, a novel inflammation based prognostic score, and long-term outcomes among patients with colorectal liver metastases (CRLM) after hepatic resection.We retrospectively investigated 106 patients who underwent hepatic resection for CRLM and explored the relationship between CRP/Alb ratio and long-term...

article

Optimal Lymphadenectomy for Duodenal Adenocarcinoma: Does the Number Alone Matter?

Taro Sakamoto, Akio Saiura, Yoshihiro Ono, Yoshihiro Mise, more

Annals of Surgical Oncology > 2017 > 24 > 11 > 3368-3375

Background Duodenal adenocarcinoma (DA) is a rare disease, and the optimal extent of lymphadenectomy and the role of limited resection remain controversial. Objective The aim of our study was to assess the pattern of regional lymph node spread of DA and to determine the optimal extent of resection. Methods A total of 65 patients who underwent curative resection for DA at our institution from 1989...

article

Survival benefit of hepatic resection for hepatocellular carcinoma beyond the Barcelona Clinic Liver Cancer classification

Kenei Furukawa, Hiroaki Shiba, Takashi Horiuchi, Yoshihiro Shirai, more

Journal of Hepato‐Biliary‐Pancreatic Sciences > 24 > 4 > 199 - 205

Background The Barcelona Clinic Liver Cancer (BCLC) classification is the most widely used staging system for hepatocellular carcinoma (HCC), but its prognostic ability in patients after resection has not been yet validated. The aim of this study was to evaluate the BCLC classification among patients after resection. Methods The subjects were 196 patients who underwent hepatic resection for HCC...

article

Successful resection of a solitary metastatic liver tumor from prostate cancer 15 years after radical prostatectomy: a case report

Hironari Kawai, Hiroaki Shiba, Masaru Kanehira, Taro Sakamoto, more

Surgical Case Reports > 2017 > 3 > 1 > 1-4

Background A solitary metastatic liver tumor of prostate cancer is extremely rare because liver metastasis occurs as a part of systemic dissemination of prostate cancer. We herein report a successfully resected case of a solitary metastatic liver tumor from prostate cancer almost 15 years after radical prostatectomy. Case presentation A 70-year-old male who had undergone radical prostatectomy for...

article

Hepatic angiosarcoma mimicking hepatic epithelioid hemangioendothelioma: report of a case

Hiroaki Shiba, Taro Sakamoto, Tomonori Iida, Kenei Furukawa, more

International Cancer Conference Journal > 2017 > 6 > 1 > 29-34

A 78-year-old male was admitted to our hospital for treatment of multiple hepatic tumors, which were suspected as hepatic epithelioid hemangioendothelioma (HEHE) by percutaneous tumor needle biopsy. With a diagnosis of HEHE, the patient underwent hepatic resection. In pathological findings, the tumor was composed of numerous endothelial cells without epithelioid cells, and was diagnosed as hepatic...

article

Initial Report of Phase II Study of Adjuvant Chemotherapy of Gemcitabine with Nafamostat Mesilate for Pancreatic Cancer

Tadashi Uwagawa, Taro Sakamoto, Yuichi Nakaseko, Yuki Takano, more

Journal of the American College of Surgeons > 2016 > 223 > 4(S2) > e46

article

Assessment of subcuticular suture for prevention of surgical site infection in hepatobiliary and pancreatic surgery

Hiroaki Shiba, Yoshihiro Shirai, Taro Sakamoto, Takashi Horiuchi, more

Journal of the American College of Surgeons > 2015 > 221 > 4 Supplement 2 > e92

article

Preoperative platelet to lymphocyte ratio predicts outcome of patients with pancreatic ductal adenocarcinoma after pancreatic resection

Yoshihiro Shirai, Hiroaki Shiba, Taro Sakamoto, Takashi Horiuchi, more

Surgery > 2015 > 158 > 2 > 360-365

Inflammation plays a crucial role in tumor growth, metastasis, and survival. The preoperative platelet-to-lymphocyte ratio (PLR) has been reported as a significant prognostic indicators in several digestive malignancies. Our objective was to evaluate whether preoperative PLR is a prognostic index in resected pancreatic ductal adenocarcinoma.Data from 131 patients who underwent pancreatic resection...

article

Phase I trial of S-1 every other day in combination with gemcitabine/cisplatin for inoperable biliary tract cancer

Tadashi Uwagawa, Taro Sakamoto, Kyohei Abe, Norimitsu Okui, more

Cancer Chemotherapy and Pharmacology > 2015 > 75 > 1 > 191-196

Purpose To date, gemcitabine-based or fluoropyrimidine-based regimens are recommended for unresectable advanced biliary tract cancer. Then, we conducted a phase I study of gemcitabine/cisplatin and S-1 that is an oral fluoropyrimidine. The aim of this study was to determine the dose-limiting toxicity (DLT), maximum-tolerated dose, and a recommended phase II dose of S-1. Response was assessed as a...

article

Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging in Caenorhabditis elegans

Taro Sakamoto, Kana Maebayashi, Yasuhito Nakagawa, Hirotaka Imai

Genes to Cells > 19 > 10 > 778 - 792

The glutathione peroxidase (GPx) family is a major antioxidant enzyme family that catalyzes the reduction of a variety of hydroperoxides. GPxs are divided into selenium‐ and nonselenium‐containing GPxs. Because of their efficient antioxidant activity, which depends on the presence of the amino acid residue selenocysteine, selenium‐containing GPxs have been the subject of many studies. However, the...

article

Successful liver transplantation from a living donor with asymptomatic pulmonary cryptococcosis

Michinori Matsumoto, Yoshiaki Kita, Takeshi Gocho, Shigeki Wakiyama, more

Liver Transplantation > 17 > 3 > 351 - 353

article

Simple method for isolation of glyceraldehyde 3‐phosphate dehydrogenase and the improvement of myofibril gel properties

Yuji MIYAGUCHI, Taro SAKAMOTO, Shun SASAKI, Koji NAKADE, more

Animal Science Journal > 82 > 1 > 136 - 143

Porcine glycoliytic enzyme, glyceraldehyde 3‐phosphate dehydrogenase (G3PD) was prepared effectively by a combination of ethylene diamine tetra‐acetate (EDTA) pretreatment and affinity purification. After salting out of porcine sarcoplasmic proteins (SP) with ammonium sulfate at 75% saturation, the obtained supernatant (SP‐f3) was treated with EDTA, leaving G3PD in the supernatant (G3PD‐E) and most...

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INFONA - science communication portal

Search results for: Taro Sakamoto

Blood loss in laparoscopic distal pancreatectomy could be underestimated

A collaborative workflow between pathologists and deep learning for the evaluation of tumour cellularity in lung adenocarcinoma

Incidental abdominal lymph node metastases from a known breast cancer in resected specimen of invasive pancreatic ductal adenocarcinoma: report of a case

Radical resection of an initially unresectable intrahepatic cholangiocarcinoma after chemotherapy with using gemcitabine, cisplatin, and S-1: report of a case

Secreted d‐aspartate oxidase functions in C. elegans reproduction and development

Risk stratification using a novel liver functional reserve score of combination prothrombin time–international normalized ratio to albumin ratio and albumin in patients with hepatocellular carcinoma

Laparoscopic fenestration for a huge symptomatic splenic cyst in a patient with Gaucher’s disease

Repeated Clostridium difficile infection after living donor liver transplantation

Impact of the C-reactive protein to albumin ratio on long-term outcomes after hepatic resection for colorectal liver metastases

Optimal Lymphadenectomy for Duodenal Adenocarcinoma: Does the Number Alone Matter?

Survival benefit of hepatic resection for hepatocellular carcinoma beyond the Barcelona Clinic Liver Cancer classification

Successful resection of a solitary metastatic liver tumor from prostate cancer 15 years after radical prostatectomy: a case report

Hepatic angiosarcoma mimicking hepatic epithelioid hemangioendothelioma: report of a case

Initial Report of Phase II Study of Adjuvant Chemotherapy of Gemcitabine with Nafamostat Mesilate for Pancreatic Cancer

Assessment of subcuticular suture for prevention of surgical site infection in hepatobiliary and pancreatic surgery

Preoperative platelet to lymphocyte ratio predicts outcome of patients with pancreatic ductal adenocarcinoma after pancreatic resection

Phase I trial of S-1 every other day in combination with gemcitabine/cisplatin for inoperable biliary tract cancer

Deletion of the four phospholipid hydroperoxide glutathione peroxidase genes accelerates aging in Caenorhabditis elegans

Successful liver transplantation from a living donor with asymptomatic pulmonary cryptococcosis

Simple method for isolation of glyceraldehyde 3‐phosphate dehydrogenase and the improvement of myofibril gel properties

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