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Combined chemotherapy is used for the treatment of a number of malignancies such as breast cancer. The target of these antineoplastic agents is nuclear DNA, although it is not restricted to malignant cells. The aim of the present study was to assess DNA damage in peripheral blood lymphocytes (PBLs) of breast cancer patients subjected to combined adjuvant chemotherapy (5-fluorouracil, epirubicin and...
In patients with oral cavity epidermoid cancer without palpable nodes, the standard cervical treatment is supraomohyoid dissection; nevertheless, lymphatic mapping with sentinel node (SN) biopsy has been useful and allows the identification of a group of patients where neck dissection may be prevented. The objective of this study was to examine which factors diagnose the possibility of metastasis...
Introduction Treatment to the neck of patients with oral tongue cancer (OTC) without palpable nodes (cN0) is controversial. Elective neck dissection (END) could lead to over-treating more than 50% and follow-up indicates high regional recurrence. Decision to perform the surgery depends on the risk of hidden node metastases (NM). Objective The objective of this study was to assess the prevalence...
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