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Integral to neuropathic pain is a reciprocal interaction between tumor necrosis factor-α (TNF) production and the α 2 -adrenergic receptor response, offering an attractive therapeutic target. The effects of varying levels of brain TNF on α 2 -adrenergic regulation of cyclic AMP (cAMP) production in the hippocampus and sciatic nerve were investigated during the development and amitriptyline...