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Background
Transforming growth factor (TGF)‐β1 exerts inhibitory effects on keratinocyte proliferation.
Objectives
To examine whether Smad7, a known inhibitor of TGF‐β1 signalling, is involved in psoriasis‐associated keratinocyte hyperproliferation.
Methods
Smad7 was evaluated in skin sections of patients with psoriasis and healthy controls and in mice with Aldara‐induced skin pathology by real‐time...
Several biomaterials have been proposed to treat anal fistula alone or in combination with other surgical procedures aiming to reduce recurrence rates while minimizing continence impairment. More recently a porcine dermal matrix injection has been proposed as infill biomaterial to treat fistulae. We propose an approach consisting of non‐cutting seton positioning followed several weeks later by flap...
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