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The study was undertaken to examine the status of Na + , K + -ATPase in aged rat brain and to verify if any alteration of this enzyme in aged brain could be related to an oxidative damage. The crude synaptosomes from rat brain were exposed in vitro to an oxidative stress in the form of a combination of Fe 2+ (100 μM) and ascorbate (2 mM) for up to 2 h when increased lipid...