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So far no pharmacogenetic/genomic study has been conducted specifically for anxiety disorders. Some of the presented results, however, do pertain to such disorders. For example, pharmacokinetic aspects of antidepressant drug therapy likely also apply to patients with anxiety disorders, and several genetic polymorphisms in the cytochrome P450 (CYP) gene family and drug transporter molecules, such as...
Hintergrund Psychotraumata gelten als Risikofaktor für die Entwicklung einer Reihe psychiatrischer Störungen. Obwohl 40–90 % der Bevölkerung im Laufe ihres Lebens einem traumatischen Ereignis ausgesetzt sind, kommt es nur bei einem Teil zur Entwicklung von Erkrankungen. In den letzten Jahren sind zahlreiche Studien erschienen, die epigenetische Veränderungen, wie DNA-Methylierung, Histonmodifikation...
A concatenation of data implicates a hyperactivity of the hypothalamus pituitary adrenal (HPA)-axis in the pathogenesis of depression and its normalization as a necessary predecessor of clinical response to antidepressant drugs. In addition, regulation of the HPA-axis has been shown to be dependent on sex hormones. We therefore investigated gender differences in HPA-axis regulation in depression and...
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