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Chemotherapy-induced cell death is linked to apoptosis, and there is increasing evidence that multidrug-resistance in cancer cells may be the result of a decrease in the ability of a cell to initiate apoptosis in response to cytotoxic agents. In previous studies, we synthesized two classes of electrophilic tocopheryl quinones (TQ), nonarylating α-TQ and arylating γ-and δ-TQ, and found that γ-and δ-TQ,...
Cytotoxicities of tocopherols (α-T, γ-T, δ-T), their para (α-TQ, γ-TQ, δ-TQ)-and ortho (Tocored)-quinone oxidation products, the synthetic quinone analog of γ-TQ containing a methyl group substituted for the phytyl side-chain (TMCQ) and the synthetic quinone analog of Tocored containing a methyl group substituted for the phytyl side-chain (PR) were measured in acute lymphoblastic leukemia cell lines...
We found previously that [d]-α-tocopherol (α-T) and [d]-γ-tocopherol (γ-T) are lipid antioxidants (thiobarbituric acid test) in model systems containing arachidonic acid (AA), cumene hydroperoxide, and Fe 3+ and in smooth muscle cell (SMC) cultures challenged with AA. We now show that [d]-α-tocopherylquinone (α-TQ), [d]-δ-tocopherylquinone (δ-TQ), and [d]-γ-tocopherylquinone (γ-TQ) are...
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