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Different clinicians may do the same work in different ways, depending on their preferences and level of expertise. The nature and amount of clinical support required also varies with the knowledge level of the clinician: novice clinicians may require guidance at each and every stage of the process, while experienced clinicians like to have a free hand and need guidance only when in doubt. We describe...
NMN deamidase (PncC) is a bacterial enzyme involved in NAD biosynthesis. We have previously demonstrated that PncC is structurally distinct from other known amidohydrolases. Here, we extended PncC characterization by mutating all potential catalytic residues and assessing their individual roles in catalysis through kinetic analyses. Inspection of these residues’ spatial arrangement in the active site,...
Nicotinate phosphoribosyltransferase (NaPRT, EC 2.4.2.11) catalyzes the conversion of nicotinate (Na) to nicotinate mononucleotide, the first reaction of the Preiss-Handler pathway for the biosynthesis of NAD + . Even though NaPRT activity has been described to be responsible for the ability of Na to increase NAD + levels in human cells more effectively than nicotinamide (Nam), so...
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