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Na+,K+-ATPase plays an essential role in mammalian blastocoel formation (cavitation) by driving trans-epithelial sodium transport. Previously, the α1 and β1 subunit isoforms of this enzyme were identified in preimplantation mouse embryos and were assumed to be responsible for this function. Here we show that mRNAs encoding an additional α subunit isoform (α3) and the remaining two β subunit isoforms...
Most genes involved in preimplantation morphogenetic events in the mouse are activated at or soon after the onset of embryonic genome expression in the 2-cell stage, and are continuously transcribed thereafter. Thus post-transcriptional regulatory mechanisms are likely to be important in developmental timing (Kidder, 1992). This is true for the gene encoding the catalytic (α) subunit of Na + ...
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