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Pharmacological models of psychosis bring a unique tool for studying brain disconnection in humans as well as in animals. Even though several electrophysiological biomarkers have been already described in schizophrenia, little is known about EEG biomarkers in pharmacological models of psychosis and about the translational validity of these data. Studies on EEG brain connectivity in rodents under these...
Schizophrenia has been associated with disrupted neural networks, which can be documented by the changes in EEG. NMDA antagonists as well as 5-HT2 agonists induce psychosis-like symptoms in animals and humans.Spectral analyses of NMDA antagonists/5-HT2 agonists have been performed by many authors, however no EEG coherence and spectra was analyzed with a higher number of cortical electrodes.The aim...
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