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Patients with glioblastoma die from local relapse despite surgery and high-dose radiotherapy. Resistance to radiotherapy is thought to be due to efficient DNA double-strand break (DSB) repair in stem-like cells able to survive DNA damage and repopulate the tumor. We used clinical samples and patient-derived glioblastoma stem cells (GSCs) to confirm that the DSB repair protein RAD51 is highly expressed...
Historically, recombinant membrane protein production has been a major challenge meaning that many fewer membrane protein structures have been published than those of soluble proteins. However, there has been a recent, almost exponential increase in the number of membrane protein structures being deposited in the Protein Data Bank. This suggests that empirical methods are now available that can ensure...
The 4th order Crystal band pass filter has been designed and realized at a frequency of 71.61MHz with low insertion loss, high rejection at stop band and good input-output return loss. A coupled resonator ladder topology is used to realize the filter. AT-cut High Frequency Fundamental Mode (HFFM) crystal resonators are used. Four crystal resonators are used to meet the required specification. The...
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